Solid-phase synthesis of hydrogen-bond surrogate-derived α-helices

Gianluca Dimartino; Deyun Wang; Ross N. Chapman; Paramjit S. Arora

doi:10.1021/ol0506516

Solid-phase synthesis of hydrogen-bond surrogate-derived α-helices

Gianluca Dimartino
, Deyun Wang
, Ross N. Chapman
, Paramjit S. Arora

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

(Chemical Equation Presented) This report describes the solid-phase synthesis of hydrogen-bond surrogate-derived artificial α-helices by a ring-closing metathesis reaction. From a series of metathesis catalysts evaluated for the synthesis of these helices, the Hoveyda-Grubbs catalyst was found to afford high yields of the macrocycle irrespective of the peptide sequence.

Original language	English
Pages (from-to)	2389-2392
Number of pages	4
Journal	Organic Letters
Volume	7
Issue number	12
DOIs	https://doi.org/10.1021/ol0506516
State	Published - 9 Jun 2005
Externally published	Yes

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10.1021/ol0506516

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title = "Solid-phase synthesis of hydrogen-bond surrogate-derived α-helices",

abstract = "(Chemical Equation Presented) This report describes the solid-phase synthesis of hydrogen-bond surrogate-derived artificial α-helices by a ring-closing metathesis reaction. From a series of metathesis catalysts evaluated for the synthesis of these helices, the Hoveyda-Grubbs catalyst was found to afford high yields of the macrocycle irrespective of the peptide sequence.",

author = "Gianluca Dimartino and Deyun Wang and Chapman, \{Ross N.\} and Arora, \{Paramjit S.\}",

year = "2005",

month = jun,

day = "9",

doi = "10.1021/ol0506516",

language = "English",

volume = "7",

pages = "2389--2392",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

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T1 - Solid-phase synthesis of hydrogen-bond surrogate-derived α-helices

AU - Dimartino, Gianluca

AU - Wang, Deyun

AU - Chapman, Ross N.

AU - Arora, Paramjit S.

PY - 2005/6/9

Y1 - 2005/6/9

N2 - (Chemical Equation Presented) This report describes the solid-phase synthesis of hydrogen-bond surrogate-derived artificial α-helices by a ring-closing metathesis reaction. From a series of metathesis catalysts evaluated for the synthesis of these helices, the Hoveyda-Grubbs catalyst was found to afford high yields of the macrocycle irrespective of the peptide sequence.

AB - (Chemical Equation Presented) This report describes the solid-phase synthesis of hydrogen-bond surrogate-derived artificial α-helices by a ring-closing metathesis reaction. From a series of metathesis catalysts evaluated for the synthesis of these helices, the Hoveyda-Grubbs catalyst was found to afford high yields of the macrocycle irrespective of the peptide sequence.

UR - https://www.scopus.com/pages/publications/20544463029

U2 - 10.1021/ol0506516

DO - 10.1021/ol0506516

M3 - Article

C2 - 15932205

AN - SCOPUS:20544463029

SN - 1523-7060

VL - 7

SP - 2389

EP - 2392

JO - Organic Letters

JF - Organic Letters

IS - 12

ER -

Solid-phase synthesis of hydrogen-bond surrogate-derived α-helices

Abstract

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