Soft-tissue Sarcoma of the Hand: Patient Characteristics, Treatment, and Oncologic Outcomes

Jonathan Lans, Kai Lou C. Yue, René M. Castelein, David I. Suster, G. Petur Nielsen, Neal C. Chen, Santiago A.Lozano Calderon

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Introduction:The aim of this study was to describe patient characteristics, treatment, and oncologic outcomes of soft-tissue sarcomas (STSs) of the hand.Methods:Sixty-nine STSs of the hand in adult patients treated at a tertiary referral center were retrospectively included. We describe patient and tumor characteristics along with oncologic outcomes.Results:Epithelioid sarcoma (23%) was the most common histologic subtype, followed by synovial sarcoma (15%). Of all tumors, 17 (25%) were grade I, 22 (32%) were grade II, and 30 (44%) were grade III. The 5-year disease-free survival for epithelioid sarcomas was 75% with a disease survival of 100%, along with a metastatic rate of 15%. Of the patients with a synovial sarcoma, 40% developed metastases, and the 5-year disease-free survival was 68% and the 5-year disease survival was 73%.Conclusion:Hand STSs are aggressive tumors with a high metastatic potential. Even with adequate oncologic treatment, long-term clinical follow-up (10 years) in these tumors is advised. The treating surgical oncologist should not be deceived by their smaller size.

Original languageEnglish
Pages (from-to)E297-E307
JournalThe Journal of the American Academy of Orthopaedic Surgeons
Issue number6
StatePublished - 15 Mar 2021
Externally publishedYes


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