Sodium MRI of multiple sclerosis

Maria Petracca, Lazar Fleysher, Niels Oesingmann, Matilde Inglese

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


Multiple sclerosis (MS) is the most common cause of non-traumatic disability in young adults. The mechanisms underlying neurodegeneration and disease progression are poorly understood, in part as a result of the lack of non-invasive methods to measure and monitor neurodegeneration in vivo. Sodium MRI is a topic of increasing interest in MS research as it allows the metabolic characterization of brain tissue in vivo, and integration with the structural information provided by 1H MRI, helping in the exploration of pathogenetic mechanisms and possibly offering insights into disease progression and monitoring of treatment outcomes. We present an up-to-date review of the sodium MRI application in MS organized into four main sections: (i) biological and pathogenetic role of sodium; (ii) brief overview of sodium imaging techniques; (iii) results of sodium MRI application in clinical studies; and (iv) future perspectives.

Original languageEnglish
Pages (from-to)153-161
Number of pages9
JournalNMR in Biomedicine
Issue number2
StatePublished - 1 Feb 2016


  • Axonal degeneration
  • Multiple sclerosis
  • Sodium MRI


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