Sodium long-component T2* mapping in human brain at 7 tesla

Lazar Fleysher, Niels Oesingmann, Bernd Stoeckel, Robert I. Grossman, Matilde Inglese

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Sodium (23Na) MRI may provide unique information about the cellular and metabolic integrity of the brain. The quantification of tissue sodium concentration from 23Na images with nonzero echo time (TE) requires knowledge of tissue-specific parameters that influence the single-quantum sodium signal such as transverse (T2) relaxation times. We report the sodium (23Na) long component of the effective transverse relaxation time T2* values obtained at 7 T in several brain regions from six healthy volunteers. A two-point protocol based on a gradient-echo sequence optimized for the least error per given imaging time was used (TE1 = 12 ms; TE2 = 37 ms; averaged N1 = 5; N2 = 15 times; pulse repetition time = 130 ms). The results reveal that long T2* component of tissue sodium (mean ± standard deviation) varied between cerebrospinal fluid (54 ± 4 ms) and gray (28 ± 2 ms) and white (29 ± 2 ms) matter structures. The results also show that the long T2* component increases as a function of the main static field B0, indicating that correlation time of sodium ion motion is smaller than the time-scale defined by the Larmor frequency. These results are a prerequisite for the quantification of tissue sodium concentration from 23Na MRI scans with nonzero echo time, will contribute to the design of future measurements (such as triple-quantum imaging), and themselves may be of clinical utility.

Original languageEnglish
Pages (from-to)1338-1341
Number of pages4
JournalMagnetic Resonance in Medicine
Issue number5
StatePublished - Nov 2009
Externally publishedYes


  • Brain
  • High magnetic field
  • MR imaging
  • Sodium
  • Transverse relaxation time


Dive into the research topics of 'Sodium long-component T2* mapping in human brain at 7 tesla'. Together they form a unique fingerprint.

Cite this