Sodium imaging as a marker of tissue injury in patients with multiple sclerosis

M. Inglese; N. Oesingmann; W. Zaaraoui; J. P. Ranjeva; L. Fleysher

doi:10.1016/j.msard.2013.03.009

Sodium imaging as a marker of tissue injury in patients with multiple sclerosis

M. Inglese, N. Oesingmann, W. Zaaraoui, J. P. Ranjeva, L. Fleysher

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

Recent studies have suggested that intra-axonal sodium accumulation contribute to axonal degeneration in patients with MS. Advances in MRI hardware and software allow acquisition of brain sodium signal in vivo. This review begins with a summary of the experimental evidence for impairment of sodium homeostasis in MS. Then, MRI methods for sodium acquisition are reviewed and the application of the techniques in patients with MS is discussed. Sodium imaging and ultra-high field MRI have the potential to provide tissue-specific markers of neurodegeneration in MS.

Original language	English
Pages (from-to)	263-269
Number of pages	7
Journal	Multiple Sclerosis and Related Disorders
Volume	2
Issue number	4
DOIs	https://doi.org/10.1016/j.msard.2013.03.009
State	Published - Oct 2013

Keywords

Multiple
Multiple-quantum filtering
Sclerosis
Sodium imaging
Ultra-high magnetic field

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title = "Sodium imaging as a marker of tissue injury in patients with multiple sclerosis",

abstract = "Recent studies have suggested that intra-axonal sodium accumulation contribute to axonal degeneration in patients with MS. Advances in MRI hardware and software allow acquisition of brain sodium signal in vivo. This review begins with a summary of the experimental evidence for impairment of sodium homeostasis in MS. Then, MRI methods for sodium acquisition are reviewed and the application of the techniques in patients with MS is discussed. Sodium imaging and ultra-high field MRI have the potential to provide tissue-specific markers of neurodegeneration in MS.",

keywords = "Multiple, Multiple-quantum filtering, Sclerosis, Sodium imaging, Ultra-high magnetic field",

author = "M. Inglese and N. Oesingmann and W. Zaaraoui and Ranjeva, {J. P.} and L. Fleysher",

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AU - Inglese, M.

AU - Oesingmann, N.

AU - Zaaraoui, W.

AU - Ranjeva, J. P.

AU - Fleysher, L.

PY - 2013/10

Y1 - 2013/10

N2 - Recent studies have suggested that intra-axonal sodium accumulation contribute to axonal degeneration in patients with MS. Advances in MRI hardware and software allow acquisition of brain sodium signal in vivo. This review begins with a summary of the experimental evidence for impairment of sodium homeostasis in MS. Then, MRI methods for sodium acquisition are reviewed and the application of the techniques in patients with MS is discussed. Sodium imaging and ultra-high field MRI have the potential to provide tissue-specific markers of neurodegeneration in MS.

AB - Recent studies have suggested that intra-axonal sodium accumulation contribute to axonal degeneration in patients with MS. Advances in MRI hardware and software allow acquisition of brain sodium signal in vivo. This review begins with a summary of the experimental evidence for impairment of sodium homeostasis in MS. Then, MRI methods for sodium acquisition are reviewed and the application of the techniques in patients with MS is discussed. Sodium imaging and ultra-high field MRI have the potential to provide tissue-specific markers of neurodegeneration in MS.

KW - Multiple

KW - Multiple-quantum filtering

KW - Sclerosis

KW - Sodium imaging

KW - Ultra-high magnetic field

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M3 - Review article

AN - SCOPUS:84880132007

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SP - 263

EP - 269

JO - Multiple Sclerosis and Related Disorders

JF - Multiple Sclerosis and Related Disorders

IS - 4

ER -

Sodium imaging as a marker of tissue injury in patients with multiple sclerosis

Abstract

Keywords

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