TY - JOUR
T1 - Social support and resilience to stress across the life span
T2 - A neurobiologic framework
AU - Ozbay, Fatih
AU - Fitterling, Heidi
AU - Charney, Dennis
AU - Southwick, Steven
PY - 2008/8
Y1 - 2008/8
N2 - This review discusses selected neurobiologic and genetic factors - including noradrenergic and hypothalamic-pituitary-adrenal axis markers, oxytocin, pathways, and serotonin transporter and brain-derived neurotrophic factor gene polymorphisms - in the context of resilience to stress, with an emphasis on social support. Social support's impact on medical and psychiatric health outcomes is reviewed, and putative mediators are discussed. The reviewed literature indicates that social support is exceptionally important to maintaining good physical and psychological health in the presence of genetic, developmental, and other environmental risks. Future studies should continue to explore the neurobiologic factors associated with social support's contribution to stress resilience.
AB - This review discusses selected neurobiologic and genetic factors - including noradrenergic and hypothalamic-pituitary-adrenal axis markers, oxytocin, pathways, and serotonin transporter and brain-derived neurotrophic factor gene polymorphisms - in the context of resilience to stress, with an emphasis on social support. Social support's impact on medical and psychiatric health outcomes is reviewed, and putative mediators are discussed. The reviewed literature indicates that social support is exceptionally important to maintaining good physical and psychological health in the presence of genetic, developmental, and other environmental risks. Future studies should continue to explore the neurobiologic factors associated with social support's contribution to stress resilience.
UR - http://www.scopus.com/inward/record.url?scp=48749103958&partnerID=8YFLogxK
U2 - 10.1007/s11920-008-0049-7
DO - 10.1007/s11920-008-0049-7
M3 - Review article
C2 - 18627668
AN - SCOPUS:48749103958
SN - 1523-3812
VL - 10
SP - 304
EP - 310
JO - Current Psychiatry Reports
JF - Current Psychiatry Reports
IS - 4
ER -