SNCA variants are associated with increased risk for multiple system atrophy

Sonja W. Scholz, Henry Houlden, Claudia Schulte, Manu Sharma, Abi Li, Daniela Berg, Anna Melchers, Reema Paudel, J. Raphael Gibbs, Javier Simon-Sanchez, Coro Paisan-Ruiz, Jose Bras, Jinhui Ding, Honglei Chen, Bryan J. Traynor, Sampath Arepalli, Ryan R. Zonozi, Tamas Revesz, Janice Holton, Nick WoodAndrew Lees, Wolfgang Oertel, Ullrich Wüllner, Stefano Goldwurm, Maria Teresa Pellecchia, Thomas Illig, Olaf Riess, Hubert H. Fernandez, Ramon L. Rodriguez, Michael S. Okun, Werner Poewe, Gregor K. Wenning, John A. Hardy, Andrew B. Singleton, Thomas Gasser

Research output: Contribution to journalArticlepeer-review

242 Scopus citations

Abstract

To test whether the synucleinopathies Parkinson's disease and multiple system atrophy (MSA) share a common genetic etiology, we performed a candidate single nucleotide polymorphism (SNP) association study of the 384 most associated SNPs in a genome-wide association study of Parkinson's disease in 413 MSA cases and 3,974 control subjects. The 10 most significant SNPs were then replicated in additional 108 MSA cases and 537 controls. SNPs at the SNCA locus were significantly associated with risk for increased risk for the development of MSA (combined p = 5.5 × 1012; odds ratio 6.2).

Original languageEnglish
Pages (from-to)610-614
Number of pages5
JournalAnnals of Neurology
Volume65
Issue number5
DOIs
StatePublished - May 2009
Externally publishedYes

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