Snatch-and-Grab Inhibitors to Fight the Flu

Adolfo García-Sastre

doi:10.1016/j.cell.2019.05.033

Snatch-and-Grab Inhibitors to Fight the Flu

Adolfo García-Sastre

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

Transcription of viral mRNA in cells infected with influenza viruses involves capturing and cleaving the first 10–20 nucleotides of 5′ capped host mRNAs to be used as primers in viral RNA synthesis. A newly developed inhibitor of the viral endonuclease responsible for this cap-snatching shows therapeutic efficacy for the treatment of influenza. To view this Bench to Bedside, open or download the PDF.

Original language	English
Pages (from-to)	1367
Number of pages	1
Journal	Cell
Volume	177
Issue number	6
DOIs	https://doi.org/10.1016/j.cell.2019.05.033
State	Published - 30 May 2019

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10.1016/j.cell.2019.05.033

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title = "Snatch-and-Grab Inhibitors to Fight the Flu",

abstract = "Transcription of viral mRNA in cells infected with influenza viruses involves capturing and cleaving the first 10–20 nucleotides of 5′ capped host mRNAs to be used as primers in viral RNA synthesis. A newly developed inhibitor of the viral endonuclease responsible for this cap-snatching shows therapeutic efficacy for the treatment of influenza. To view this Bench to Bedside, open or download the PDF.",

author = "Adolfo Garc{\'i}a-Sastre",

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N2 - Transcription of viral mRNA in cells infected with influenza viruses involves capturing and cleaving the first 10–20 nucleotides of 5′ capped host mRNAs to be used as primers in viral RNA synthesis. A newly developed inhibitor of the viral endonuclease responsible for this cap-snatching shows therapeutic efficacy for the treatment of influenza. To view this Bench to Bedside, open or download the PDF.

AB - Transcription of viral mRNA in cells infected with influenza viruses involves capturing and cleaving the first 10–20 nucleotides of 5′ capped host mRNAs to be used as primers in viral RNA synthesis. A newly developed inhibitor of the viral endonuclease responsible for this cap-snatching shows therapeutic efficacy for the treatment of influenza. To view this Bench to Bedside, open or download the PDF.

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DO - 10.1016/j.cell.2019.05.033

M3 - Short survey

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SN - 0092-8674

VL - 177

SP - 1367

JO - Cell

JF - Cell

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ER -

Snatch-and-Grab Inhibitors to Fight the Flu

Abstract

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