Snare Tip Soft Coagulation vs Argon Plasma Coagulation vs No Margin Treatment After Large Nonpedunculated Colorectal Polyp Resection: a Randomized Trial

Douglas K. Rex, Gregory B. Haber, Mouen Khashab, Amit Rastogi, Muhammad K. Hasan, Christopher J. DiMaio, Nikhil A. Kumta, Satish Nagula, Stuart Gordon, Firas Al-Kawas, Jerome D. Waye, Hadie Razjouyan, Charles E. Dye, Matthew T. Moyer, Jeremiah Shultz, Rachel E. Lahr, Poi Yu Sofia Yuen, Rebekah Dixon, La Keisha Boyd, Heiko Pohl

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background & Aims: Thermal treatment of the defect margin after endoscopic mucosal resection (EMR) of large nonpedunculated colorectal lesions reduces the recurrence rate. Both snare tip soft coagulation (STSC) and argon plasma coagulation (APC) have been used for thermal margin treatment, but there are few data directly comparing STSC with APC for this indication. Methods: We performed a randomized 3-arm trial in 9 US centers comparing STSC with APC with no margin treatment (control) of defects after EMR of colorectal nonpedunculated lesions ≥15 mm. The primary end point was the presence of residual lesion at first follow-up. Results: There were 384 patients and 414 lesions randomized, and 308 patients (80.2%) with 328 lesions completed ≥1 follow-up. The proportion of lesions with residual polyp at first follow-up was 4.6% with STSC, 9.3% with APC, and 21.4% with control subjects (no margin treatment). The odds of residual polyp at first follow-up were lower for STSC and APC when compared with control subjects (P = .001 and P = .01, respectively). The difference in odds was not significant between STSC and APC. STSC took less time to apply than APC (median, 3.35 vs 4.08 minutes; P = .019). Adverse event rates were low, with no difference between arms. Conclusions: In a randomized trial STSC and APC were each superior to no thermal margin treatment after EMR. STSC was faster to apply than APC. Because STSC also results in lower cost and plastic waste than APC (APC requires an additional device), our study supports STSC as the preferred thermal margin treatment after colorectal EMR. (Clinicaltrials.gov, Number NCT03654209.)

Original languageEnglish
Pages (from-to)552-561.e4
JournalClinical Gastroenterology and Hepatology
Volume22
Issue number3
DOIs
StatePublished - Mar 2024

Keywords

  • Colonoscopy
  • Colorectal Adenoma
  • Endoscopic Mucosal Resection
  • Lateral Spreading Lesions
  • Nonpedunculated Polyps

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