Smooth pursuit eye movement disorder and its psychobiologic correlates in unmedicated schizophrenics

Larry J. Siever; Daniel P. van Kammen; Markku Linnoila; Ina Alterman; Theodore Hare; Dennis L. Murphy

doi:10.1016/0006-3223(86)90223-4

Smooth pursuit eye movement disorder and its psychobiologic correlates in unmedicated schizophrenics

Larry J. Siever, Daniel P. van Kammen, Markku Linnoila, Ina Alterman, Theodore Hare, Dennis L. Murphy

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35 Scopus citations

Abstract

The accuracy of smooth pursuit eye movements (SPEMs) was evaluated electrooculographically in 14 medication-free schizophrenics. Concentrations of monoamine metabolites and gamma-amino-butyric acid (GABA) were measured in their cerebrospinal fluid (CSF). Ventricular-brain ratios (VBR) were determined by computed axial tomography (CT scan). Premorbid adjustment was evaluated by the Phillips Scale. The SPEMs of eight of the patients were reevaluated after 2 weeks of treatment with either prazosin or pimozide. No consistent significant correlations were found between SPEM accuracy and CSF metabolite concentrations, VBR, or premorbid adjustment. SPEM accuracy was not correlated with number of days off medication and was significantly correlated when measured before and during medication.

Original language	English
Pages (from-to)	1167-1174
Number of pages	8
Journal	Biological Psychiatry
Volume	21
Issue number	12
DOIs	https://doi.org/10.1016/0006-3223(86)90223-4
State	Published - Oct 1986
Externally published	Yes

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title = "Smooth pursuit eye movement disorder and its psychobiologic correlates in unmedicated schizophrenics",

abstract = "The accuracy of smooth pursuit eye movements (SPEMs) was evaluated electrooculographically in 14 medication-free schizophrenics. Concentrations of monoamine metabolites and gamma-amino-butyric acid (GABA) were measured in their cerebrospinal fluid (CSF). Ventricular-brain ratios (VBR) were determined by computed axial tomography (CT scan). Premorbid adjustment was evaluated by the Phillips Scale. The SPEMs of eight of the patients were reevaluated after 2 weeks of treatment with either prazosin or pimozide. No consistent significant correlations were found between SPEM accuracy and CSF metabolite concentrations, VBR, or premorbid adjustment. SPEM accuracy was not correlated with number of days off medication and was significantly correlated when measured before and during medication.",

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T1 - Smooth pursuit eye movement disorder and its psychobiologic correlates in unmedicated schizophrenics

AU - Siever, Larry J.

AU - van Kammen, Daniel P.

AU - Linnoila, Markku

AU - Alterman, Ina

AU - Hare, Theodore

AU - Murphy, Dennis L.

PY - 1986/10

Y1 - 1986/10

N2 - The accuracy of smooth pursuit eye movements (SPEMs) was evaluated electrooculographically in 14 medication-free schizophrenics. Concentrations of monoamine metabolites and gamma-amino-butyric acid (GABA) were measured in their cerebrospinal fluid (CSF). Ventricular-brain ratios (VBR) were determined by computed axial tomography (CT scan). Premorbid adjustment was evaluated by the Phillips Scale. The SPEMs of eight of the patients were reevaluated after 2 weeks of treatment with either prazosin or pimozide. No consistent significant correlations were found between SPEM accuracy and CSF metabolite concentrations, VBR, or premorbid adjustment. SPEM accuracy was not correlated with number of days off medication and was significantly correlated when measured before and during medication.

AB - The accuracy of smooth pursuit eye movements (SPEMs) was evaluated electrooculographically in 14 medication-free schizophrenics. Concentrations of monoamine metabolites and gamma-amino-butyric acid (GABA) were measured in their cerebrospinal fluid (CSF). Ventricular-brain ratios (VBR) were determined by computed axial tomography (CT scan). Premorbid adjustment was evaluated by the Phillips Scale. The SPEMs of eight of the patients were reevaluated after 2 weeks of treatment with either prazosin or pimozide. No consistent significant correlations were found between SPEM accuracy and CSF metabolite concentrations, VBR, or premorbid adjustment. SPEM accuracy was not correlated with number of days off medication and was significantly correlated when measured before and during medication.

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DO - 10.1016/0006-3223(86)90223-4

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AN - SCOPUS:0022922386

SN - 0006-3223

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SP - 1167

EP - 1174

JO - Biological Psychiatry

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ER -

Smooth pursuit eye movement disorder and its psychobiologic correlates in unmedicated schizophrenics

Abstract

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