TY - JOUR
T1 - Smoking and the antioxidant ascorbic acid
T2 - Plasma, leukocyte, and cervicovaginal cell concentrations in normal healthy women
AU - Basu, Jayasri
AU - Mikhail, Magdy S.
AU - Payraudeau, Patricia H.
AU - Palan, Prabhudas R.
AU - Romney, Seymour L.
N1 - Funding Information:
From the Department of Obstetrics and Gynecology, Albert Einstein College of Medicine. Supported in part by the Friends of Gynecology Cancer Research, Albert Einstein College of Medicine, and a grant-in-aid from Hoffmann-La Roche, Inc., Nutley, New Jersey. Presented at the Thirty-seventh Annual Meeting of the Society for Gynecologic Investigation, St. Louis, Missouri, March 21-24, 1990. Reprint requests: Jayasri Basu, PhD, Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, Ullmann Building, Room 111, 1300 Morris Park Ave., Bronx, NY 10461.
PY - 1990/12
Y1 - 1990/12
N2 - The influence of cigarette smoking on the plasma, leukocyte, and cervicovaginal cell ascorbic acid levels in 46 healthy smokers and healthy nonsmokers was investigated. Coded peripheral venous blood and cervicovaginal lavage specimens obtained after informed consent were analyzed simultaneously for their ascorbic acid content. The findings suggest that smoking affects the levels and distribution of ascorbic acid. In smokers (n = 16), the number of exfoliated cervicovaginal epithelial cells and leukocyte ascorbic acid levels was significantly higher (p < 0.01, p < 0.05, respectively) compared with nonsmokers (n = 30). In addition, cervicovaginal cell ascorbic acid, plasma reduced and total ascorbic acid levels were significantly lower (p < 0.001, p < 0.01, p < 0.01, respectively). The exfoliated epithelial cell ascorbic acid levels in nonsmokers was fourfold greater than that of leukocytes. The implications of these findings within the context of free radical-induced cellular pertubations in smokers are discussed.
AB - The influence of cigarette smoking on the plasma, leukocyte, and cervicovaginal cell ascorbic acid levels in 46 healthy smokers and healthy nonsmokers was investigated. Coded peripheral venous blood and cervicovaginal lavage specimens obtained after informed consent were analyzed simultaneously for their ascorbic acid content. The findings suggest that smoking affects the levels and distribution of ascorbic acid. In smokers (n = 16), the number of exfoliated cervicovaginal epithelial cells and leukocyte ascorbic acid levels was significantly higher (p < 0.01, p < 0.05, respectively) compared with nonsmokers (n = 30). In addition, cervicovaginal cell ascorbic acid, plasma reduced and total ascorbic acid levels were significantly lower (p < 0.001, p < 0.01, p < 0.01, respectively). The exfoliated epithelial cell ascorbic acid levels in nonsmokers was fourfold greater than that of leukocytes. The implications of these findings within the context of free radical-induced cellular pertubations in smokers are discussed.
KW - Cigarette smoking
KW - cell count
KW - cervix cancer risk factors
KW - lavage technique
KW - reduced ascorbic acid
KW - total ascorbic acid
KW - vitamin C
UR - https://www.scopus.com/pages/publications/0025668821
U2 - 10.1016/0002-9378(90)90779-7
DO - 10.1016/0002-9378(90)90779-7
M3 - Article
C2 - 2256507
AN - SCOPUS:0025668821
SN - 0002-9378
VL - 163
SP - 1948
EP - 1952
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 6 PART 1
ER -