TY - JOUR
T1 - Small increases in circulating luteinizing hormone (LH) concentrations shortly before human chorionic gonadotropin (hCG) are associated with reduced in vitro fertilization (IVF) pregnancy rate
AU - Munabi, Abraham K.
AU - King, Dixie
AU - Bender, Samuel
AU - Bustillo, Maria
AU - Dorfmann, Andrew
AU - Schulman, Joseph D.
PY - 1990/12
Y1 - 1990/12
N2 - The effects of slight elevations in serum LH just before hCG administration on IVF cycle outcome were studied in 219 women undergoing retrieval. One hundred seven patients were stimulated using human menopausal gonadotropin (hMG), and 112 received clomiphene citrate and hMG. Serum LH, estradiol (E2), and progesterone concentrations were measured before and during controlled ovarian stimulation. Retrospectively the women were subdivided into three groups based on serum LH before hCG: Group I, <50% LH rise from baseline (BL) value (mean of day 2 and day 7); Group II, LH rise ≥50% but <2×BL; and, Group III, LH rise ≥2×BL. The fertilization and cleavage rates were similar in all groups. However, a ≥50% rise in serum LH before hCG was associated with a significantly reduced IVF pregnancy rate.
AB - The effects of slight elevations in serum LH just before hCG administration on IVF cycle outcome were studied in 219 women undergoing retrieval. One hundred seven patients were stimulated using human menopausal gonadotropin (hMG), and 112 received clomiphene citrate and hMG. Serum LH, estradiol (E2), and progesterone concentrations were measured before and during controlled ovarian stimulation. Retrospectively the women were subdivided into three groups based on serum LH before hCG: Group I, <50% LH rise from baseline (BL) value (mean of day 2 and day 7); Group II, LH rise ≥50% but <2×BL; and, Group III, LH rise ≥2×BL. The fertilization and cleavage rates were similar in all groups. However, a ≥50% rise in serum LH before hCG was associated with a significantly reduced IVF pregnancy rate.
KW - in vitro fertilization
KW - luteinizing hormone rise
KW - pregnancy rate
UR - http://www.scopus.com/inward/record.url?scp=0025608820&partnerID=8YFLogxK
U2 - 10.1007/BF01130581
DO - 10.1007/BF01130581
M3 - Article
C2 - 2127600
AN - SCOPUS:0025608820
SN - 0740-7769
VL - 7
SP - 310
EP - 313
JO - Journal of in Vitro Fertilization and Embryo Transfer
JF - Journal of in Vitro Fertilization and Embryo Transfer
IS - 6
ER -