Small increases in circulating luteinizing hormone (LH) concentrations shortly before human chorionic gonadotropin (hCG) are associated with reduced in vitro fertilization (IVF) pregnancy rate

Abraham K. Munabi, Dixie King, Samuel Bender, Maria Bustillo, Andrew Dorfmann, Joseph D. Schulman

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The effects of slight elevations in serum LH just before hCG administration on IVF cycle outcome were studied in 219 women undergoing retrieval. One hundred seven patients were stimulated using human menopausal gonadotropin (hMG), and 112 received clomiphene citrate and hMG. Serum LH, estradiol (E2), and progesterone concentrations were measured before and during controlled ovarian stimulation. Retrospectively the women were subdivided into three groups based on serum LH before hCG: Group I, <50% LH rise from baseline (BL) value (mean of day 2 and day 7); Group II, LH rise ≥50% but <2×BL; and, Group III, LH rise ≥2×BL. The fertilization and cleavage rates were similar in all groups. However, a ≥50% rise in serum LH before hCG was associated with a significantly reduced IVF pregnancy rate.

Original languageEnglish
Pages (from-to)310-313
Number of pages4
JournalJournal of in Vitro Fertilization and Embryo Transfer
Volume7
Issue number6
DOIs
StatePublished - Dec 1990
Externally publishedYes

Keywords

  • in vitro fertilization
  • luteinizing hormone rise
  • pregnancy rate

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