Small-field radiotherapy in combination with concomitant chemotherapy for locally advanced pancreatic carcinoma

Koichi Tokuuye, Minako Sumi, Yoshikazu Kagami, Shigeyuki Murayama, Hiroshi Ikeda, Masafumi Ikeda, Takuji Okusaka, Hideki Ueno, Shuichi Okada

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Purpose: To evaluate the effectiveness of small-field radiotherapy in combination with concomitant 5-fluorouracil (5FU) or cisplatin for locally advanced pancreatic carcinoma. Materials and methods: From November 1993 to January 1999, 53 patients underwent continuous 5FU infusion at 200 mg/m2 (27 patients) or a 30-min cisplatin infusion at 5 mg/m2/day (26 patients) just prior to each irradiation. The radiation field was limited to cover the primary and the paraaortic regions at celiac and supramesenteric axis levels. A total dose of 50.4 Gy in 28 sessions was given in 5.6 weeks. Results: Median and 1-year survival rates were 10.2 months and 35.2%, respectively. Local failure occurred in 19 patients (36%) and liver metastases in 16 patients (30%). All local recurrences occurred only within the radiation field. Conclusions: Median survival rates were comparable to other studies. Because local failure occurred only within the radiation field, the use of relatively small-field radiotherapy may be justified in the treatment of locally advanced pancreatic carcinoma in addition to concurrent administration of either 5FU or cisplatin.

Original languageEnglish
Pages (from-to)327-330
Number of pages4
JournalRadiotherapy and Oncology
Volume67
Issue number3
DOIs
StatePublished - 1 Jun 2003
Externally publishedYes

Keywords

  • Chemoradiotherapy
  • Pancreatic carcinoma
  • Radiation field

Fingerprint

Dive into the research topics of 'Small-field radiotherapy in combination with concomitant chemotherapy for locally advanced pancreatic carcinoma'. Together they form a unique fingerprint.

Cite this