TY - JOUR
T1 - Small bowel capsule endoscopy for management of Crohn's disease
T2 - A retrospective tertiary care centre experience
AU - Dussault, Catherine
AU - Gower-Rousseau, Corinne
AU - Salleron, Julia
AU - Vernier-Massouille, Gwénola
AU - Branche, Julien
AU - Colombel, Jean Frédéric
AU - Maunoury, Vincent
N1 - Funding Information:
Jean Frederic Colombel has received lecture fees and research grant from Given Imaging .
PY - 2013/7
Y1 - 2013/7
N2 - Background: The role of small bowel capsule endoscopy in the management of established Crohn's disease is uncertain. Methods: A retrospective study of small bowel capsule endoscopy tests performed in a referral centre from 2008 to 2011; 77 tests were performed in patients with known Crohn's disease. Six patients were excluded due to capsule test retention. Patients were classified into 4 indication groups: unexplained anaemia (G1, n= 6); discrepancy between clinical symptoms and morphology (G2, n= 25), full assessment of Crohn's disease location (G3, n= 37) and evaluation of mucosal healing (G4, n= 3). Results: Twenty-seven (38%) patients had no lesions, 32 (45%) moderate and 12 (17%) severe lesions. Endoscopic lesions were found in 4/6 (67%) G1 patients, 11/25 (44%) G2 and 28/37 (76%) G3 (p<. 0.03). Three months after endoscopy was performed, 38/71 patients experienced a change in their treatment that was significantly associated with the severity of endoscopic lesions and with test indications; in 60%, 20% and 58% of patients from G1, G2 and G3, respectively (p<. 0.01). Conclusion: Small bowel capsule endoscopy resulted in management changes in the majority of patients with established Crohn's disease.
AB - Background: The role of small bowel capsule endoscopy in the management of established Crohn's disease is uncertain. Methods: A retrospective study of small bowel capsule endoscopy tests performed in a referral centre from 2008 to 2011; 77 tests were performed in patients with known Crohn's disease. Six patients were excluded due to capsule test retention. Patients were classified into 4 indication groups: unexplained anaemia (G1, n= 6); discrepancy between clinical symptoms and morphology (G2, n= 25), full assessment of Crohn's disease location (G3, n= 37) and evaluation of mucosal healing (G4, n= 3). Results: Twenty-seven (38%) patients had no lesions, 32 (45%) moderate and 12 (17%) severe lesions. Endoscopic lesions were found in 4/6 (67%) G1 patients, 11/25 (44%) G2 and 28/37 (76%) G3 (p<. 0.03). Three months after endoscopy was performed, 38/71 patients experienced a change in their treatment that was significantly associated with the severity of endoscopic lesions and with test indications; in 60%, 20% and 58% of patients from G1, G2 and G3, respectively (p<. 0.01). Conclusion: Small bowel capsule endoscopy resulted in management changes in the majority of patients with established Crohn's disease.
KW - Crohn's disease
KW - Therapeutic management
KW - Videocapsule endoscopy
UR - https://www.scopus.com/pages/publications/84881243635
U2 - 10.1016/j.dld.2012.11.004
DO - 10.1016/j.dld.2012.11.004
M3 - Article
AN - SCOPUS:84881243635
SN - 1590-8658
VL - 45
SP - 558
EP - 561
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
IS - 7
ER -