TY - JOUR
T1 - Small-animal SPECT and SPECT/CT
T2 - Application in cardiovascular research
AU - Golestani, Reza
AU - Wu, Chao
AU - Tio, René A.
AU - Zeebregts, Clark J.
AU - Petrov, Artiom D.
AU - Beekman, Freek J.
AU - Dierckx, Rudi A.J.O.
AU - Boersma, Hendrikus H.
AU - Slart, Riemer H.J.A.
N1 - Funding Information:
Acknowledgment We thank Ralph Houston for his help during the preparation of the manuscript. The work of R. Golestani was supported by an unrestricted grant from Siemens.
PY - 2010/8
Y1 - 2010/8
N2 - Preclinical cardiovascular research using noninvasive radionuclide and hybrid imaging systems has been extensively developed in recent years. Single photon emission computed tomography (SPECT) is based on the molecular tracer principle and is an established tool in noninvasive imaging. SPECT uses gamma cameras and collimators to form projection data that are used to estimate (dynamic) 3-D tracer distributions in vivo. Recent developments in multipinhole collimation and advanced image reconstruction have led to sub-millimetre and sub-half-millimetre resolution SPECT in rats and mice, respectively. In this article we review applications of microSPECT in cardiovascular research in which information about the function and pathology of the myocardium, vessels and neurons is obtained. We give examples on how diagnostic tracers, new therapeutic interventions, pre- and postcardiovascular event prognosis, and functional and pathophysiological heart conditions can be explored by microSPECT, using small-animal models of cardiovascular disease.
AB - Preclinical cardiovascular research using noninvasive radionuclide and hybrid imaging systems has been extensively developed in recent years. Single photon emission computed tomography (SPECT) is based on the molecular tracer principle and is an established tool in noninvasive imaging. SPECT uses gamma cameras and collimators to form projection data that are used to estimate (dynamic) 3-D tracer distributions in vivo. Recent developments in multipinhole collimation and advanced image reconstruction have led to sub-millimetre and sub-half-millimetre resolution SPECT in rats and mice, respectively. In this article we review applications of microSPECT in cardiovascular research in which information about the function and pathology of the myocardium, vessels and neurons is obtained. We give examples on how diagnostic tracers, new therapeutic interventions, pre- and postcardiovascular event prognosis, and functional and pathophysiological heart conditions can be explored by microSPECT, using small-animal models of cardiovascular disease.
KW - Cardiovascular imaging
KW - microSPECT
KW - microSPECT/CT
UR - http://www.scopus.com/inward/record.url?scp=77956182695&partnerID=8YFLogxK
U2 - 10.1007/s00259-009-1321-8
DO - 10.1007/s00259-009-1321-8
M3 - Review article
C2 - 20069298
AN - SCOPUS:77956182695
SN - 1619-7070
VL - 37
SP - 1766
EP - 1777
JO - European Journal of Nuclear Medicine and Molecular Imaging
JF - European Journal of Nuclear Medicine and Molecular Imaging
IS - 9
ER -