Slowing of voluntary and involuntary saccades: An early sign in spinocerebellar ataxia type 7

Andrew K. Oh, Kathleen M. Jacobson, Joanna C. Jen, Robert W. Baloh

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

We describe quantitative oculomotor findings in a patient with subclinical spinocerebellar ataxia type 7 (SCA7) and a borderline mutation of 38 CAG repeats and her daughter with SCA7 and 46 repeats. Both subjects demonstrated significant slowing of voluntary and involuntary saccades, but retinal examination was normal. Smooth pursuit and fixation suppression of VOR were mildly impaired. Slow saccades may be the earliest neurologic finding even in asymptomatic SCA7 patients with normal ocular fundi. The SCA7 mutation probably has an early impact on brainstem fast eye movement centers.

Original languageEnglish
Pages (from-to)801-804
Number of pages4
JournalAnnals of Neurology
Volume49
Issue number6
DOIs
StatePublished - 2001
Externally publishedYes

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