Sleep-related hypermotor epilepsy activated by rapid eye movement sleep

Xiaoli Wang, Lara V. Marcuse, Lang Jin, Ying Zhang, Wenjuan Zhang, Beibei Chen, Na Yuan, Bi Wang, Yonghong Liu

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Most sleep-related seizures occur during non-rapid eye movement (NREM) sleep, particularly during stage changes. Sleep-related hypermotor epilepsy (SHE) is a rare epileptic syndrome characterized by paroxysmal motor seizures, mainly arising from NREM sleep. Here, we report a patient with SHE who had seven seizures captured on video-EEG-polysomnography during REM sleep. Ictal semiology of this patient ranged from brief paroxysmal arousals to hypermotor seizures. On EEG-polysomnography, the spontaneous arousals were more frequent during REM than NREM sleep, with a considerably higher arousal index in REM sleep (20/hour). While the reason for seizures during REM sleep in this patient is unclear, we speculate that the threshold and mechanisms of arousal during different sleep stages may be related to the occurrence of seizures. [Published with video sequences on www.epilepticdisorders.com].

Original languageEnglish
Pages (from-to)65-69
Number of pages5
JournalEpileptic Disorders
Volume20
Issue number1
DOIs
StatePublished - Feb 2018

Keywords

  • REM sleep
  • nocturnal frontal lobe epilepsy
  • paroxysmal arousal
  • sleep-related hypermotor seizure

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