Sleep duration and insomnia in the elderly: Associations with blood pressure variability and carotid artery remodeling

Michiaki Nagai, Satoshi Hoshide, Mami Nishikawa, Kazuyuki Shimada, Kazuomi Kario

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


background Recent studies have shown that short and long sleep durations and insomnia are associated with increased home-measured blood pressure (BP) variability, which in turn has a relationship with arterial stiffness. However, the determinants for visit-to-visit systolic blood pressure (SBP) variability have rarely been investigated in relation to sleep duration, insomnia, and carotid arterial stiffness. method The subjects were 201 elderly individuals (79.9 ± 6.4 years old) with one or more cardiovascular risks. Based on 12 visits, visit-to-visit BP variability (expressed as a coefficient of variation [CV]) and d (maximum - minimum) BP were measured. Self-reported sleep duration and insomnia questionnaires were used to classify the patients according to sleep duration period and insomnia status. results After multivariable adjustment, long sleep duration (= 9 hours per night) had significant positive associations with SBP d (P > 0.05), while persistent insomnia had significant positive associations with SBP CV (P > 0.05) and d (P > 0.01). Additionally, significant interactions were found in terms of long sleep duration by carotid artery stiffness parameter β (P > 0.05), persistent insomnia by intima-media thickness (P > 0.01), and persistent insomnia by stiffness parameter β (P > 0.05) for SBP d. conclusion In elderly patients at high risk for cardiovascular disease, long sleep duration as well as persistent insomnia were significantly associated with higher visit-to-visit BP variability. Long sleep duration and persistent insomnia each had synergetic interactions with carotid artery stiffness and with visit-to-visit BP variability.

Original languageEnglish
Pages (from-to)981-989
Number of pages9
JournalAmerican Journal of Hypertension
Issue number8
StatePublished - Aug 2013
Externally publishedYes


  • Arterial stiffness
  • Blood pressure
  • Hypertension
  • Insomnia
  • Sleep duration
  • Visit-to-visit BP variability


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