@inproceedings{b79cf2640bdc4e7d892e1e0569392a9f,
title = "SlC30A8 is a major target of humoral autoimmunity in type 1 diabetes and a predictive marker in prediabetes",
abstract = "Type 1A diabetes (T1D) results from autoimmunity targeted at a limited number of molecules that are expressed in the pancreatic β cell. Putative novel autoantigen candidates were identified from microarray expression profiling of human and rodent islet cells. The highest ranking candidate was Slc30A8 (zinc transporter 8; ZnT8), which was screened by radioimmunoprecipitation assays against new-onset T1D and prediabetic sera. Such assays detected 63% of subjects with new-onset diabetes, but fewer than 2% of controls, 3% of those with type 2 diabetes, and 10% of patients with other autoimmune disorders. ZnT8 autoantibodies were found, however, in 26% of T1D subjects previously classified as autoantibody-negative on the basis of existing markers (GADA, IA2 A, IAA, and ICA). We conclude that SLC30A8 provides an important additional and independent predictive marker for T1D.",
keywords = "Autoantibodies, ICA, Zinc transporter",
author = "Wenzlau, {Janet M.} and Ong Moua and Sarkar, {Suparna A.} and Liping Yu and Marian Rewers and Eisenbarth, {George S.} and Davidson, {Howard W.} and Hutton, {John C.}",
year = "2008",
month = dec,
doi = "10.1196/annals.1447.029",
language = "English",
isbn = "9781573317337",
series = "Annals of the New York Academy of Sciences",
publisher = "Blackwell Publishing Inc.",
pages = "256--259",
booktitle = "Immunology of Diabetes V From Bench to Bedside",
}