TY - JOUR
T1 - SLC16 Family
T2 - From Atomic Structure to Human Disease
AU - Bosshart, Patrick D.
AU - Charles, Roch Philippe
AU - Garibsingh, Rachel Ann A.
AU - Schlessinger, Avner
AU - Fotiadis, Dimitrios
N1 - Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2021/1
Y1 - 2021/1
N2 - The solute carrier 16 (SLC16) family represents a diverse group of membrane proteins mediating the transport of monocarboxylates across biological membranes. Family members show a variety of functional roles ranging from nutrient transport and intracellular pH regulation to thyroid hormone homeostasis. Changes in the expression levels and transport function of certain SLC16 transporters are manifested in severe health disorders including cancer, diabetes, and neurological disorders. L-Lactate-transporting SLC16 family members play essential roles in the metabolism of certain tumors and became validated drug targets. This review illuminates the SLC16 family under a new light using structural information obtained from a SLC16 homolog. Furthermore, the role of these transporters in cancer metabolism and how their inhibition can contribute to anticancer therapy are discussed.
AB - The solute carrier 16 (SLC16) family represents a diverse group of membrane proteins mediating the transport of monocarboxylates across biological membranes. Family members show a variety of functional roles ranging from nutrient transport and intracellular pH regulation to thyroid hormone homeostasis. Changes in the expression levels and transport function of certain SLC16 transporters are manifested in severe health disorders including cancer, diabetes, and neurological disorders. L-Lactate-transporting SLC16 family members play essential roles in the metabolism of certain tumors and became validated drug targets. This review illuminates the SLC16 family under a new light using structural information obtained from a SLC16 homolog. Furthermore, the role of these transporters in cancer metabolism and how their inhibition can contribute to anticancer therapy are discussed.
KW - L-lactate
KW - Warburg effect
KW - membrane protein
KW - metabolic symbiosis
KW - monocarboxylate transporter
KW - solute carrier 16 family
UR - http://www.scopus.com/inward/record.url?scp=85089587620&partnerID=8YFLogxK
U2 - 10.1016/j.tibs.2020.07.005
DO - 10.1016/j.tibs.2020.07.005
M3 - Review article
C2 - 32828650
AN - SCOPUS:85089587620
VL - 46
SP - 28
EP - 40
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
SN - 0376-5067
IS - 1
ER -