Skeletal Muscle Nitrate as a Regulator of Systemic Nitric Oxide Homeostasis

Barbora Piknova; Alan N. Schechter; Ji Won Park; Anni Vanhatalo; Andrew M. Jones

doi:10.1249/JES.0000000000000272

Skeletal Muscle Nitrate as a Regulator of Systemic Nitric Oxide Homeostasis

Barbora Piknova, Alan N. Schechter, Ji Won Park, Anni Vanhatalo, Andrew M. Jones

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Nonenzymatic nitric oxide (NO) generation via the reduction of nitrate and nitrite ions, along with remarkably high levels of nitrate ions in skeletal muscle, have been described recently. Skeletal muscle nitrate storage may be critical for maintenance of NO homeostasis in healthy aging, and nitrate supplementation may be useful for the treatment of specific pathophysiologies and for enhancing normal functions.

Original language	English
Pages (from-to)	2-13
Number of pages	12
Journal	Exercise and Sport Sciences Reviews
Volume	50
Issue number	1
DOIs	https://doi.org/10.1249/JES.0000000000000272
State	Published - 1 Jan 2022
Externally published	Yes

Keywords

Exercise
Health
Nitrate
Nitric oxide
Nitrite
Skeletal muscle
Xanthine oxidoreductase

Access to Document

10.1249/JES.0000000000000272

Cite this

@article{fa72388342a54552bb637442b0234a73,

title = "Skeletal Muscle Nitrate as a Regulator of Systemic Nitric Oxide Homeostasis",

abstract = "Nonenzymatic nitric oxide (NO) generation via the reduction of nitrate and nitrite ions, along with remarkably high levels of nitrate ions in skeletal muscle, have been described recently. Skeletal muscle nitrate storage may be critical for maintenance of NO homeostasis in healthy aging, and nitrate supplementation may be useful for the treatment of specific pathophysiologies and for enhancing normal functions.",

keywords = "Exercise, Health, Nitrate, Nitric oxide, Nitrite, Skeletal muscle, Xanthine oxidoreductase",

author = "Barbora Piknova and Schechter, {Alan N.} and Park, {Ji Won} and Anni Vanhatalo and Jones, {Andrew M.}",

note = "Funding Information: This study was supported by the National Institutes of Health (ZIA DK 0251041-14 to Dr Alan N. Schechter) and the BBSRC U.S. Partnering award (BB/S020632/1 to Dr Andrew M. Jones and Dr Anni Vanhatalo). Publisher Copyright: {\textcopyright} 2022 Lippincott Williams and Wilkins. All rights reserved.",

year = "2022",

month = jan,

day = "1",

doi = "10.1249/JES.0000000000000272",

language = "English",

volume = "50",

pages = "2--13",

journal = "Exercise and Sport Sciences Reviews",

issn = "0091-6331",

publisher = "Lippincott Williams and Wilkins Ltd.",

number = "1",

}

TY - JOUR

T1 - Skeletal Muscle Nitrate as a Regulator of Systemic Nitric Oxide Homeostasis

AU - Piknova, Barbora

AU - Schechter, Alan N.

AU - Park, Ji Won

AU - Vanhatalo, Anni

AU - Jones, Andrew M.

N1 - Funding Information: This study was supported by the National Institutes of Health (ZIA DK 0251041-14 to Dr Alan N. Schechter) and the BBSRC U.S. Partnering award (BB/S020632/1 to Dr Andrew M. Jones and Dr Anni Vanhatalo). Publisher Copyright: © 2022 Lippincott Williams and Wilkins. All rights reserved.

PY - 2022/1/1

Y1 - 2022/1/1

N2 - Nonenzymatic nitric oxide (NO) generation via the reduction of nitrate and nitrite ions, along with remarkably high levels of nitrate ions in skeletal muscle, have been described recently. Skeletal muscle nitrate storage may be critical for maintenance of NO homeostasis in healthy aging, and nitrate supplementation may be useful for the treatment of specific pathophysiologies and for enhancing normal functions.

AB - Nonenzymatic nitric oxide (NO) generation via the reduction of nitrate and nitrite ions, along with remarkably high levels of nitrate ions in skeletal muscle, have been described recently. Skeletal muscle nitrate storage may be critical for maintenance of NO homeostasis in healthy aging, and nitrate supplementation may be useful for the treatment of specific pathophysiologies and for enhancing normal functions.

KW - Exercise

KW - Health

KW - Nitrate

KW - Nitric oxide

KW - Nitrite

KW - Skeletal muscle

KW - Xanthine oxidoreductase

UR - http://www.scopus.com/inward/record.url?scp=85122380130&partnerID=8YFLogxK

U2 - 10.1249/JES.0000000000000272

DO - 10.1249/JES.0000000000000272

M3 - Article

C2 - 34669624

AN - SCOPUS:85122380130

SN - 0091-6331

VL - 50

SP - 2

EP - 13

JO - Exercise and Sport Sciences Reviews

JF - Exercise and Sport Sciences Reviews

IS - 1

ER -

Skeletal Muscle Nitrate as a Regulator of Systemic Nitric Oxide Homeostasis

Abstract

Keywords

Access to Document

Fingerprint

Cite this