Skeletal Muscle Nitrate as a Regulator of Systemic Nitric Oxide Homeostasis

Barbora Piknova, Alan N. Schechter, Ji Won Park, Anni Vanhatalo, Andrew M. Jones

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Nonenzymatic nitric oxide (NO) generation via the reduction of nitrate and nitrite ions, along with remarkably high levels of nitrate ions in skeletal muscle, have been described recently. Skeletal muscle nitrate storage may be critical for maintenance of NO homeostasis in healthy aging, and nitrate supplementation may be useful for the treatment of specific pathophysiologies and for enhancing normal functions.

Original languageEnglish
Pages (from-to)2-13
Number of pages12
JournalExercise and Sport Sciences Reviews
Issue number1
StatePublished - 1 Jan 2022
Externally publishedYes


  • Exercise
  • Health
  • Nitrate
  • Nitric oxide
  • Nitrite
  • Skeletal muscle
  • Xanthine oxidoreductase


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