Site of Conversion of Tryptophan into Nicotinic Acid in Man

Selma E. Snyderman; Katherine C. Ketron; Rosario Carretero; L. Emmett Holt

doi:10.3181/00379727-70-16996

Site of Conversion of Tryptophan into Nicotinic Acid in Man

Selma E. Snyderman, Katherine C. Ketron, Rosario Carretero, L. Emmett Holt

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Abstract

The intravenous administration of one gram of L-tryptophan to infants on constant diets gave a prompt and large rise in the urinary N1methyl nicotinamide which was equal in magnitude to that provoked by oral administration of the tryptophan. In view of these findings, the conversion of tryptophan to N1methyl nicotinamide in man seems to be mediated by the body tissues rather than by bacterial synthesis in the gastrointestinal tract.

Original language	English
Pages (from-to)	569-571
Number of pages	3
Journal	Experimental Biology and Medicine
Volume	70
Issue number	4
DOIs	https://doi.org/10.3181/00379727-70-16996
State	Published - Apr 1949
Externally published	Yes

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title = "Site of Conversion of Tryptophan into Nicotinic Acid in Man",

abstract = "The intravenous administration of one gram of L-tryptophan to infants on constant diets gave a prompt and large rise in the urinary N1methyl nicotinamide which was equal in magnitude to that provoked by oral administration of the tryptophan. In view of these findings, the conversion of tryptophan to N1methyl nicotinamide in man seems to be mediated by the body tissues rather than by bacterial synthesis in the gastrointestinal tract.",

author = "Snyderman, \{Selma E.\} and Ketron, \{Katherine C.\} and Rosario Carretero and Holt, \{L. Emmett\}",

note = "Funding Information: This study was supported in part by grants from the Dazian Foundation for Medical Research, the Sugar Research Foundation, and Roche Anniversary Foundation. ",

year = "1949",

month = apr,

doi = "10.3181/00379727-70-16996",

language = "English",

volume = "70",

pages = "569--571",

journal = "Experimental Biology and Medicine",

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T1 - Site of Conversion of Tryptophan into Nicotinic Acid in Man

AU - Snyderman, Selma E.

AU - Ketron, Katherine C.

AU - Carretero, Rosario

AU - Holt, L. Emmett

N1 - Funding Information: This study was supported in part by grants from the Dazian Foundation for Medical Research, the Sugar Research Foundation, and Roche Anniversary Foundation.

PY - 1949/4

Y1 - 1949/4

N2 - The intravenous administration of one gram of L-tryptophan to infants on constant diets gave a prompt and large rise in the urinary N1methyl nicotinamide which was equal in magnitude to that provoked by oral administration of the tryptophan. In view of these findings, the conversion of tryptophan to N1methyl nicotinamide in man seems to be mediated by the body tissues rather than by bacterial synthesis in the gastrointestinal tract.

AB - The intravenous administration of one gram of L-tryptophan to infants on constant diets gave a prompt and large rise in the urinary N1methyl nicotinamide which was equal in magnitude to that provoked by oral administration of the tryptophan. In view of these findings, the conversion of tryptophan to N1methyl nicotinamide in man seems to be mediated by the body tissues rather than by bacterial synthesis in the gastrointestinal tract.

UR - https://www.scopus.com/pages/publications/78651006658

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DO - 10.3181/00379727-70-16996

M3 - Article

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AN - SCOPUS:78651006658

SN - 0037-9727

VL - 70

SP - 569

EP - 571

JO - Experimental Biology and Medicine

JF - Experimental Biology and Medicine

IS - 4

ER -

Site of Conversion of Tryptophan into Nicotinic Acid in Man

Abstract

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