TY - JOUR
T1 - Sisters of women with premature ovarian failure may not be ideal ovum donors
AU - Sung, Linda
AU - Booth, Georgie
AU - Bustillo, María
AU - Karstaedt, Alexis
AU - Mukherjee, Tanmoy
AU - Copperman, Alan B.
PY - 1997/5
Y1 - 1997/5
N2 - Objectives: To determine whether the sisters of women with premature ovarian failure (POF) showed a response to gonadotropin stimulation comparable to that of anonymous ovum donors. Design: Historical cohort study. Setting: Records of 228 consecutive ovum recipients in an academic assisted reproductive technology program. Patient(s): Criteria for inclusion were oocyte recipients age ≤ 40 years, FSH > 18 mIU/mL (conversion factor to SI unit, 1.00), and/or failure to respond appropriately to controlled ovarian hyperstimulation (COH). Seventy-nine recipients were classified on the basis of whether they received oocytes from anonymous donors (group I, n = 66) or sister donors (group II, n = 13). Main Outcome Measure(s): Controlled ovarian hyperstimulation response, pregnancy rates (PRs), and implantation rates. Result(s): The ages of the donors to groups I and II were comparable (31.1 ± 16.7 versus 29.8 ± 7.2 years), but those in group II exhibited a higher baseline FSH level (12.8 ± 2.1 versus 8.6 ± 5.8 mIU/mL). Group II versus I had a relative risk of 5.1 for cancellation (4 of 13 [30.8%] versus 4 of 66 [16.1%], respectively). In completed cycles of groups I and II, respectively, there was no difference in serum E2 on the day of hCG administration (2,356 ± 826 versus 1,847 ± 843 pg/mL; conversion factor to SI unit, 3.671), number of oocytes retrieved (25 ± 14 versus 22 ± 13), number of embryos transferred (4.4 ± 2.1 versus 4.0 ± 1.0), spontaneous abortion rate (22.7% versus 25.0%), PR (35.5% versus 36.4%), and implantation rate (16.2% versus 16.4%). Conclusion(s): There is an increased cancellation rate and, consequently, an overall trend toward decreased ovarian response to gonadotropin stimulation in the sisters of patients with POF. Despite these factors, the implantation rates and PRs of embryos derived from patients reaching retrieval were similar to those from anonymous donors. We recommend counseling women with POF that their sisters may not be ideal ovum donors.
AB - Objectives: To determine whether the sisters of women with premature ovarian failure (POF) showed a response to gonadotropin stimulation comparable to that of anonymous ovum donors. Design: Historical cohort study. Setting: Records of 228 consecutive ovum recipients in an academic assisted reproductive technology program. Patient(s): Criteria for inclusion were oocyte recipients age ≤ 40 years, FSH > 18 mIU/mL (conversion factor to SI unit, 1.00), and/or failure to respond appropriately to controlled ovarian hyperstimulation (COH). Seventy-nine recipients were classified on the basis of whether they received oocytes from anonymous donors (group I, n = 66) or sister donors (group II, n = 13). Main Outcome Measure(s): Controlled ovarian hyperstimulation response, pregnancy rates (PRs), and implantation rates. Result(s): The ages of the donors to groups I and II were comparable (31.1 ± 16.7 versus 29.8 ± 7.2 years), but those in group II exhibited a higher baseline FSH level (12.8 ± 2.1 versus 8.6 ± 5.8 mIU/mL). Group II versus I had a relative risk of 5.1 for cancellation (4 of 13 [30.8%] versus 4 of 66 [16.1%], respectively). In completed cycles of groups I and II, respectively, there was no difference in serum E2 on the day of hCG administration (2,356 ± 826 versus 1,847 ± 843 pg/mL; conversion factor to SI unit, 3.671), number of oocytes retrieved (25 ± 14 versus 22 ± 13), number of embryos transferred (4.4 ± 2.1 versus 4.0 ± 1.0), spontaneous abortion rate (22.7% versus 25.0%), PR (35.5% versus 36.4%), and implantation rate (16.2% versus 16.4%). Conclusion(s): There is an increased cancellation rate and, consequently, an overall trend toward decreased ovarian response to gonadotropin stimulation in the sisters of patients with POF. Despite these factors, the implantation rates and PRs of embryos derived from patients reaching retrieval were similar to those from anonymous donors. We recommend counseling women with POF that their sisters may not be ideal ovum donors.
KW - Siblings
KW - implantation
KW - in vitro fertilization
KW - ovum recipients
KW - pregnancy
UR - http://www.scopus.com/inward/record.url?scp=0342618671&partnerID=8YFLogxK
U2 - 10.1016/S0015-0282(97)81406-9
DO - 10.1016/S0015-0282(97)81406-9
M3 - Article
C2 - 9130899
AN - SCOPUS:0342618671
SN - 0015-0282
VL - 67
SP - 912
EP - 916
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 5
ER -