Sister-chromatid exchange induced by X-ray of human lymphocytes and the effect of l-cysteine

Idida Abramovsky; Gary Vorsanger; Kurt Hirschhorn

doi:10.1016/0027-5107(78)90064-7

Sister-chromatid exchange induced by X-ray of human lymphocytes and the effect of l-cysteine

Idida Abramovsky
, Gary Vorsanger
, Kurt Hirschhorn

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

A staining technique that detects sister-chromatid exchanges (SCEs) has been used to examine the response of human lymphocyte chromosomes to various dosages of X-irradiation. The SCE frequency was markedly increased following irradiation. However, the increase was of a significantly smaller magnitude when irradiation occurred in the presence of an antimutagenic agent. Scoring SCEs may provide a useful technique for assaying the mutagenic effects of environmental carcinogens as well as the protective effects of antimutagenic agents.

Original language	English
Pages (from-to)	93-100
Number of pages	8
Journal	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume	50
Issue number	1
DOIs	https://doi.org/10.1016/0027-5107(78)90064-7
State	Published - Apr 1978

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title = "Sister-chromatid exchange induced by X-ray of human lymphocytes and the effect of l-cysteine",

abstract = "A staining technique that detects sister-chromatid exchanges (SCEs) has been used to examine the response of human lymphocyte chromosomes to various dosages of X-irradiation. The SCE frequency was markedly increased following irradiation. However, the increase was of a significantly smaller magnitude when irradiation occurred in the presence of an antimutagenic agent. Scoring SCEs may provide a useful technique for assaying the mutagenic effects of environmental carcinogens as well as the protective effects of antimutagenic agents.",

author = "Idida Abramovsky and Gary Vorsanger and Kurt Hirschhorn",

note = "Funding Information: This work was supported in part by grants No. GM-19443 and HD-02552 from The National Institutes of Health. I.A. was supported by a summer-science medical student research grant from The National Foundation-March of Dimes (No. 8-2-1). G.V. is a USPHS predoctoral trainee in human genetics (HD-00210).",

year = "1978",

month = apr,

doi = "10.1016/0027-5107(78)90064-7",

language = "English",

volume = "50",

pages = "93--100",

journal = "Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis",

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T1 - Sister-chromatid exchange induced by X-ray of human lymphocytes and the effect of l-cysteine

AU - Abramovsky, Idida

AU - Vorsanger, Gary

AU - Hirschhorn, Kurt

N1 - Funding Information: This work was supported in part by grants No. GM-19443 and HD-02552 from The National Institutes of Health. I.A. was supported by a summer-science medical student research grant from The National Foundation-March of Dimes (No. 8-2-1). G.V. is a USPHS predoctoral trainee in human genetics (HD-00210).

PY - 1978/4

Y1 - 1978/4

N2 - A staining technique that detects sister-chromatid exchanges (SCEs) has been used to examine the response of human lymphocyte chromosomes to various dosages of X-irradiation. The SCE frequency was markedly increased following irradiation. However, the increase was of a significantly smaller magnitude when irradiation occurred in the presence of an antimutagenic agent. Scoring SCEs may provide a useful technique for assaying the mutagenic effects of environmental carcinogens as well as the protective effects of antimutagenic agents.

AB - A staining technique that detects sister-chromatid exchanges (SCEs) has been used to examine the response of human lymphocyte chromosomes to various dosages of X-irradiation. The SCE frequency was markedly increased following irradiation. However, the increase was of a significantly smaller magnitude when irradiation occurred in the presence of an antimutagenic agent. Scoring SCEs may provide a useful technique for assaying the mutagenic effects of environmental carcinogens as well as the protective effects of antimutagenic agents.

UR - https://www.scopus.com/pages/publications/0018090467

U2 - 10.1016/0027-5107(78)90064-7

DO - 10.1016/0027-5107(78)90064-7

M3 - Article

C2 - 347282

AN - SCOPUS:0018090467

SN - 0027-5107

VL - 50

SP - 93

EP - 100

JO - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

JF - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

IS - 1

ER -

Sister-chromatid exchange induced by X-ray of human lymphocytes and the effect of l-cysteine

Abstract

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