TY - JOUR
T1 - Sister-chromatid exchange induced by X-ray of human lymphocytes and the effect of l-cysteine
AU - Abramovsky, Idida
AU - Vorsanger, Gary
AU - Hirschhorn, Kurt
N1 - Funding Information:
This work was supported in part by grants No. GM-19443 and HD-02552 from The National Institutes of Health. I.A. was supported by a summer-science medical student research grant from The National Foundation-March of Dimes (No. 8-2-1). G.V. is a USPHS predoctoral trainee in human genetics (HD-00210).
PY - 1978/4
Y1 - 1978/4
N2 - A staining technique that detects sister-chromatid exchanges (SCEs) has been used to examine the response of human lymphocyte chromosomes to various dosages of X-irradiation. The SCE frequency was markedly increased following irradiation. However, the increase was of a significantly smaller magnitude when irradiation occurred in the presence of an antimutagenic agent. Scoring SCEs may provide a useful technique for assaying the mutagenic effects of environmental carcinogens as well as the protective effects of antimutagenic agents.
AB - A staining technique that detects sister-chromatid exchanges (SCEs) has been used to examine the response of human lymphocyte chromosomes to various dosages of X-irradiation. The SCE frequency was markedly increased following irradiation. However, the increase was of a significantly smaller magnitude when irradiation occurred in the presence of an antimutagenic agent. Scoring SCEs may provide a useful technique for assaying the mutagenic effects of environmental carcinogens as well as the protective effects of antimutagenic agents.
UR - http://www.scopus.com/inward/record.url?scp=0018090467&partnerID=8YFLogxK
U2 - 10.1016/0027-5107(78)90064-7
DO - 10.1016/0027-5107(78)90064-7
M3 - Article
C2 - 347282
AN - SCOPUS:0018090467
VL - 50
SP - 93
EP - 100
JO - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
JF - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
SN - 0027-5107
IS - 1
ER -