Sister-chromatid exchange induced by X-ray of human lymphocytes and the effect of l-cysteine

Idida Abramovsky, Gary Vorsanger, Kurt Hirschhorn

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

A staining technique that detects sister-chromatid exchanges (SCEs) has been used to examine the response of human lymphocyte chromosomes to various dosages of X-irradiation. The SCE frequency was markedly increased following irradiation. However, the increase was of a significantly smaller magnitude when irradiation occurred in the presence of an antimutagenic agent. Scoring SCEs may provide a useful technique for assaying the mutagenic effects of environmental carcinogens as well as the protective effects of antimutagenic agents.

Original languageEnglish
Pages (from-to)93-100
Number of pages8
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume50
Issue number1
DOIs
StatePublished - Apr 1978

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