Single-stage long-segment tracheal transplantation

Eric M. Genden, Brett A. Miles, Timothy J. Harkin, Samuel DeMaria, Andrew J. Kaufman, Erica Mayland, Vivian F. Kaul, Sander S. Florman

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Tracheal transplantation has been envisioned as a viable option for reconstruction of long-segment tracheal defects. We report the first human single-stage long-segment tracheal transplantation. Narrow-band imaging and bronchoscopic biopsies demonstrate allograft vascularization and viable epithelial lining. The recipient was immunosuppressed with Tacrolimus, Mycophenolate mofetil, and corticosteroids. Six months after transplantation, the trachea is both functional and the patient is breathing without the need of a tracheostomy or stent.

Original languageEnglish
Pages (from-to)3421-3427
Number of pages7
JournalAmerican Journal of Transplantation
Issue number10
StatePublished - Oct 2021


  • clinical research/practice
  • organ procurement
  • surgical technique
  • vascularized composite and reconstructive transplantation


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