Single muscle fiber size and contractility after spinal cord injury in rats

Walter R. Frontera; Howard Choi; Gomathi Krishnan; Lisa S. Krivickas; Sunil Sabharwal; Yang D. Teng

doi:10.1002/mus.20530

Single muscle fiber size and contractility after spinal cord injury in rats

Walter R. Frontera, Howard Choi, Gomathi Krishnan, Lisa S. Krivickas, Sunil Sabharwal, Yang D. Teng

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Spinal cord injury (SCI) results in muscle weakness but the degree of impairment at the level of single fibers is not known. The purpose of this study was to examine the effects of T9-level SCI on single muscle fibers from the tibialis anterior of rats. Significant decreases in cross-sectional area (CSA), maximal force (Po), and specific force (SF = Po/CSA) were noted at 2 weeks. Atrophy and force-generating capacity were reversed at 4 weeks, but SF remained impaired. Maximum shortening velocity (Vo) did not change after injury. SCI thus appears to affect various contractile properties of single muscle fibers differently. Normal cage activity may partially restore function but new interventions are needed to restore muscle fiber quality.

Original language	English
Pages (from-to)	101-104
Number of pages	4
Journal	Muscle and Nerve
Volume	34
Issue number	1
DOIs	https://doi.org/10.1002/mus.20530
State	Published - Jul 2006
Externally published	Yes

Keywords

Chemically skinned single muscle fibers
Contusion
Myosin heavy chain isoform
Specific force
Spinal cord injury

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abstract = "Spinal cord injury (SCI) results in muscle weakness but the degree of impairment at the level of single fibers is not known. The purpose of this study was to examine the effects of T9-level SCI on single muscle fibers from the tibialis anterior of rats. Significant decreases in cross-sectional area (CSA), maximal force (Po), and specific force (SF = Po/CSA) were noted at 2 weeks. Atrophy and force-generating capacity were reversed at 4 weeks, but SF remained impaired. Maximum shortening velocity (Vo) did not change after injury. SCI thus appears to affect various contractile properties of single muscle fibers differently. Normal cage activity may partially restore function but new interventions are needed to restore muscle fiber quality.",

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AU - Frontera, Walter R.

AU - Choi, Howard

AU - Krishnan, Gomathi

AU - Krivickas, Lisa S.

AU - Sabharwal, Sunil

AU - Teng, Yang D.

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AB - Spinal cord injury (SCI) results in muscle weakness but the degree of impairment at the level of single fibers is not known. The purpose of this study was to examine the effects of T9-level SCI on single muscle fibers from the tibialis anterior of rats. Significant decreases in cross-sectional area (CSA), maximal force (Po), and specific force (SF = Po/CSA) were noted at 2 weeks. Atrophy and force-generating capacity were reversed at 4 weeks, but SF remained impaired. Maximum shortening velocity (Vo) did not change after injury. SCI thus appears to affect various contractile properties of single muscle fibers differently. Normal cage activity may partially restore function but new interventions are needed to restore muscle fiber quality.

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Single muscle fiber size and contractility after spinal cord injury in rats

Abstract

Keywords

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