Single-Cell RNA Sequencing of Blood and Ileal T Cells From Patients With Crohn's Disease Reveals Tissue-Specific Characteristics and Drug Targets

Werna T. Uniken Venema; Michiel D. Voskuil; Arnau Vich Vila; Gerben van der Vries; Bernadien H. Jansen; Bana Jabri; Klaas Nico Faber; Gerard Dijkstra; Ramnik J. Xavier; Cisca Wijmenga; Daniel B. Graham; Rinse K. Weersma; Eleonora A. Festen

doi:10.1053/j.gastro.2018.10.046

Single-Cell RNA Sequencing of Blood and Ileal T Cells From Patients With Crohn's Disease Reveals Tissue-Specific Characteristics and Drug Targets

Werna T. Uniken Venema
, Michiel D. Voskuil
, Arnau Vich Vila
, Gerben van der Vries
, Bernadien H. Jansen
, Bana Jabri
, Klaas Nico Faber
, Gerard Dijkstra
, Ramnik J. Xavier
, Cisca Wijmenga
, Daniel B. Graham
, Rinse K. Weersma
, Eleonora A. Festen

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Original language	English
Pages (from-to)	812-815.e22
Journal	Gastroenterology
Volume	156
Issue number	3
DOIs	https://doi.org/10.1053/j.gastro.2018.10.046
State	Published - Feb 2019
Externally published	Yes

Keywords

Genetics
Genome-wide Association Study
Immune Response
Inflammatory Bowel Disease

Access to Document

10.1053/j.gastro.2018.10.046

Cite this

Uniken Venema, W. T., Voskuil, M. D., Vila, A. V., van der Vries, G., Jansen, B. H., Jabri, B., Faber, K. N., Dijkstra, G., Xavier, R. J., Wijmenga, C., Graham, D. B., Weersma, R. K., & Festen, E. A. (2019). Single-Cell RNA Sequencing of Blood and Ileal T Cells From Patients With Crohn's Disease Reveals Tissue-Specific Characteristics and Drug Targets. Gastroenterology, 156(3), 812-815.e22. https://doi.org/10.1053/j.gastro.2018.10.046

@article{76bff6cc22224efd89ee2ca39ab43a9c,

title = "Single-Cell RNA Sequencing of Blood and Ileal T Cells From Patients With Crohn's Disease Reveals Tissue-Specific Characteristics and Drug Targets",

keywords = "Genetics, Genome-wide Association Study, Immune Response, Inflammatory Bowel Disease",

author = "\{Uniken Venema\}, \{Werna T.\} and Voskuil, \{Michiel D.\} and Vila, \{Arnau Vich\} and \{van der Vries\}, Gerben and Jansen, \{Bernadien H.\} and Bana Jabri and Faber, \{Klaas Nico\} and Gerard Dijkstra and Xavier, \{Ramnik J.\} and Cisca Wijmenga and Graham, \{Daniel B.\} and Weersma, \{Rinse K.\} and Festen, \{Eleonora A.\}",

note = "Funding Information: Funding Cisca Wijmenga is supported by a European Research Council (ERC) advanced grant (FP/2007-2013/ERC grant 2012-322698), a Netherlands Organisation for Scientific Research (NWO) Spinoza prize (NWO SPI 92-266), the NWO Gravitation Netherlands Organ-on-Chip Initiative (024.003.001), the Stiftelsen Kristian Gerhard Jebsen foundation (Norway), and a RuG Investment Agenda Grant for Personalized Health. Rinse K. Weersma is supported by an NWO VIDI grant (016.136.308). Eleonora A. Festen is supported by a Dutch Digestive Foundation Career Development grant (CDG 14-04). Werna T. Uniken Venema is supported by the Foundation “De Drie Lichten,” the Netherlands, and the Boehringer Ingelheim Fund. The Department of Genetics, Section Research and Development, University of Groningen, University Medical Center Groningen contributed to laboratory expenses for this study.",

year = "2019",

month = feb,

doi = "10.1053/j.gastro.2018.10.046",

language = "English",

volume = "156",

pages = "812--815.e22",

journal = "Gastroenterology",

issn = "0016-5085",

publisher = "W.B. Saunders",

number = "3",

}

Uniken Venema, WT, Voskuil, MD, Vila, AV, van der Vries, G, Jansen, BH, Jabri, B, Faber, KN, Dijkstra, G, Xavier, RJ, Wijmenga, C, Graham, DB, Weersma, RK & Festen, EA 2019, 'Single-Cell RNA Sequencing of Blood and Ileal T Cells From Patients With Crohn's Disease Reveals Tissue-Specific Characteristics and Drug Targets', Gastroenterology, vol. 156, no. 3, pp. 812-815.e22. https://doi.org/10.1053/j.gastro.2018.10.046

TY - JOUR

T1 - Single-Cell RNA Sequencing of Blood and Ileal T Cells From Patients With Crohn's Disease Reveals Tissue-Specific Characteristics and Drug Targets

AU - Uniken Venema, Werna T.

AU - Voskuil, Michiel D.

AU - Vila, Arnau Vich

AU - van der Vries, Gerben

AU - Jansen, Bernadien H.

AU - Jabri, Bana

AU - Faber, Klaas Nico

AU - Dijkstra, Gerard

AU - Xavier, Ramnik J.

AU - Wijmenga, Cisca

AU - Graham, Daniel B.

AU - Weersma, Rinse K.

AU - Festen, Eleonora A.

N1 - Funding Information: Funding Cisca Wijmenga is supported by a European Research Council (ERC) advanced grant (FP/2007-2013/ERC grant 2012-322698), a Netherlands Organisation for Scientific Research (NWO) Spinoza prize (NWO SPI 92-266), the NWO Gravitation Netherlands Organ-on-Chip Initiative (024.003.001), the Stiftelsen Kristian Gerhard Jebsen foundation (Norway), and a RuG Investment Agenda Grant for Personalized Health. Rinse K. Weersma is supported by an NWO VIDI grant (016.136.308). Eleonora A. Festen is supported by a Dutch Digestive Foundation Career Development grant (CDG 14-04). Werna T. Uniken Venema is supported by the Foundation “De Drie Lichten,” the Netherlands, and the Boehringer Ingelheim Fund. The Department of Genetics, Section Research and Development, University of Groningen, University Medical Center Groningen contributed to laboratory expenses for this study.

PY - 2019/2

Y1 - 2019/2

KW - Genetics

KW - Genome-wide Association Study

KW - Immune Response

KW - Inflammatory Bowel Disease

UR - https://www.scopus.com/pages/publications/85061005653

U2 - 10.1053/j.gastro.2018.10.046

DO - 10.1053/j.gastro.2018.10.046

M3 - Article

C2 - 30391472

AN - SCOPUS:85061005653

SN - 0016-5085

VL - 156

SP - 812-815.e22

JO - Gastroenterology

JF - Gastroenterology

IS - 3

ER -