Simultaneous management of blood flow and IOP in glaucoma

Alon Harris; Christian Jonescu-Cuypers; Bruce Martin; Larry Kagemann; Miriam Zalish; Hannah J. Garzozi

doi:10.1034/j.1600-0420.2001.079004336.x

Simultaneous management of blood flow and IOP in glaucoma

Alon Harris, Christian Jonescu-Cuypers, Bruce Martin, Larry Kagemann, Miriam Zalish, Hannah J. Garzozi

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Factors other than intraocular pressure (IOP) elevation must be involved in initiation and progression of glaucoma. An additional element in disease causation may be ischemia in the retina and optic nerve head. Ischemic damage to neurons in the CNS is similar mechanistically and histopathologically to changes seen in glaucoma. Further, glaucoma patients with normal IOP show clear evidence for cerebral and ocular ischemia. Aging and atherosclerosis reduce the ability of the eye to autoregulate blood flow when ocular perfusion pressure changes: the dependence of blood flow on perfusion pressure links ischemia to IOP. Consequently, neuroprotective treatments for glaucoma should be designed to both reduce IOP and improve ocular nutrient delivery.

Original language	English
Pages (from-to)	336-341
Number of pages	6
Journal	Acta Ophthalmologica Scandinavica
Volume	79
Issue number	4
DOIs	https://doi.org/10.1034/j.1600-0420.2001.079004336.x
State	Published - 2001
Externally published	Yes

Keywords

Carbonic anhydrase
Glaucoma
Intraocular pressure
Ischemia

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10.1034/j.1600-0420.2001.079004336.x

Cite this

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abstract = "Factors other than intraocular pressure (IOP) elevation must be involved in initiation and progression of glaucoma. An additional element in disease causation may be ischemia in the retina and optic nerve head. Ischemic damage to neurons in the CNS is similar mechanistically and histopathologically to changes seen in glaucoma. Further, glaucoma patients with normal IOP show clear evidence for cerebral and ocular ischemia. Aging and atherosclerosis reduce the ability of the eye to autoregulate blood flow when ocular perfusion pressure changes: the dependence of blood flow on perfusion pressure links ischemia to IOP. Consequently, neuroprotective treatments for glaucoma should be designed to both reduce IOP and improve ocular nutrient delivery.",

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AU - Zalish, Miriam

AU - Garzozi, Hannah J.

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AB - Factors other than intraocular pressure (IOP) elevation must be involved in initiation and progression of glaucoma. An additional element in disease causation may be ischemia in the retina and optic nerve head. Ischemic damage to neurons in the CNS is similar mechanistically and histopathologically to changes seen in glaucoma. Further, glaucoma patients with normal IOP show clear evidence for cerebral and ocular ischemia. Aging and atherosclerosis reduce the ability of the eye to autoregulate blood flow when ocular perfusion pressure changes: the dependence of blood flow on perfusion pressure links ischemia to IOP. Consequently, neuroprotective treatments for glaucoma should be designed to both reduce IOP and improve ocular nutrient delivery.

KW - Carbonic anhydrase

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Simultaneous management of blood flow and IOP in glaucoma

Abstract

Keywords

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