Similarity of insulin-dependent diabetics' and non-insulin-dependent diabetics' levels of β-hCG and unconjugated estriol with controls: No need to adjust as with alpha-fetoprotein

Mark I. Evans; Joseph E. O'Brien; Elena Dvorin; Eric L. Krivchenia; Arie Drugan; Roderick F. Hume; Mark P. Johnson

doi:10.1016/1071-5576(95)00043-7

Similarity of insulin-dependent diabetics' and non-insulin-dependent diabetics' levels of β-hCG and unconjugated estriol with controls: No need to adjust as with alpha-fetoprotein

Mark I. Evans, Joseph E. O'Brien, Elena Dvorin, Eric L. Krivchenia, Arie Drugan, Roderick F. Hume, Mark P. Johnson

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Objective: To determine if the same systematic alteration of serum values seen for alpha-fetoprotein (AFP) in diabetic patients is also seen for β- hCG and unconjugated estriol (uE3). Methods: Serum AFP, β-hCG, and uE3 results were obtained in 18,639 patients for whom complete follow-up information was obtained. Patients were divided into euglycemic (n = 18,088), insulin-requiring diabetics (n = 104), and non-insulin-requiring diabetics (n = 437), a well as by race. Results: The 20% adjustment used for AFP appropriately corrects serum values. No such systematic variation is seen for either β-hCG or uE3 by glycemic status or race. Conclusion: No adjustment for β-hCG or uE3 is necessary for diabetes for biochemical screening programs.

Original language	English
Pages (from-to)	20-22
Number of pages	3
Journal	Journal of the Society for Gynecologic Investigation
Volume	3
Issue number	1
DOIs	https://doi.org/10.1016/1071-5576(95)00043-7
State	Published - Jan 1996
Externally published	Yes

Keywords

Insulin
diabetes
multiple marker biochemical screening
screening programs

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10.1016/1071-5576(95)00043-7

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Evans, M. I., O'Brien, J. E., Dvorin, E., Krivchenia, E. L., Drugan, A., Hume, R. F., & Johnson, M. P. (1996). Similarity of insulin-dependent diabetics' and non-insulin-dependent diabetics' levels of β-hCG and unconjugated estriol with controls: No need to adjust as with alpha-fetoprotein. Journal of the Society for Gynecologic Investigation, 3(1), 20-22. https://doi.org/10.1016/1071-5576(95)00043-7

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title = "Similarity of insulin-dependent diabetics' and non-insulin-dependent diabetics' levels of β-hCG and unconjugated estriol with controls: No need to adjust as with alpha-fetoprotein",

abstract = "Objective: To determine if the same systematic alteration of serum values seen for alpha-fetoprotein (AFP) in diabetic patients is also seen for β- hCG and unconjugated estriol (uE3). Methods: Serum AFP, β-hCG, and uE3 results were obtained in 18,639 patients for whom complete follow-up information was obtained. Patients were divided into euglycemic (n = 18,088), insulin-requiring diabetics (n = 104), and non-insulin-requiring diabetics (n = 437), a well as by race. Results: The 20% adjustment used for AFP appropriately corrects serum values. No such systematic variation is seen for either β-hCG or uE3 by glycemic status or race. Conclusion: No adjustment for β-hCG or uE3 is necessary for diabetes for biochemical screening programs.",

keywords = "Insulin, diabetes, multiple marker biochemical screening, screening programs",

author = "Evans, {Mark I.} and O'Brien, {Joseph E.} and Elena Dvorin and Krivchenia, {Eric L.} and Arie Drugan and Hume, {Roderick F.} and Johnson, {Mark P.}",

year = "1996",

month = jan,

doi = "10.1016/1071-5576(95)00043-7",

language = "English",

volume = "3",

pages = "20--22",

journal = "Journal of the Society for Gynecologic Investigation",

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Evans, MI, O'Brien, JE, Dvorin, E, Krivchenia, EL, Drugan, A, Hume, RF & Johnson, MP 1996, 'Similarity of insulin-dependent diabetics' and non-insulin-dependent diabetics' levels of β-hCG and unconjugated estriol with controls: No need to adjust as with alpha-fetoprotein', Journal of the Society for Gynecologic Investigation, vol. 3, no. 1, pp. 20-22. https://doi.org/10.1016/1071-5576(95)00043-7

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Similarity of insulin-dependent diabetics' and non-insulin-dependent diabetics' levels of β-hCG and unconjugated estriol with controls

T2 - No need to adjust as with alpha-fetoprotein

AU - Evans, Mark I.

AU - O'Brien, Joseph E.

AU - Dvorin, Elena

AU - Krivchenia, Eric L.

AU - Drugan, Arie

AU - Hume, Roderick F.

AU - Johnson, Mark P.

PY - 1996/1

Y1 - 1996/1

N2 - Objective: To determine if the same systematic alteration of serum values seen for alpha-fetoprotein (AFP) in diabetic patients is also seen for β- hCG and unconjugated estriol (uE3). Methods: Serum AFP, β-hCG, and uE3 results were obtained in 18,639 patients for whom complete follow-up information was obtained. Patients were divided into euglycemic (n = 18,088), insulin-requiring diabetics (n = 104), and non-insulin-requiring diabetics (n = 437), a well as by race. Results: The 20% adjustment used for AFP appropriately corrects serum values. No such systematic variation is seen for either β-hCG or uE3 by glycemic status or race. Conclusion: No adjustment for β-hCG or uE3 is necessary for diabetes for biochemical screening programs.

AB - Objective: To determine if the same systematic alteration of serum values seen for alpha-fetoprotein (AFP) in diabetic patients is also seen for β- hCG and unconjugated estriol (uE3). Methods: Serum AFP, β-hCG, and uE3 results were obtained in 18,639 patients for whom complete follow-up information was obtained. Patients were divided into euglycemic (n = 18,088), insulin-requiring diabetics (n = 104), and non-insulin-requiring diabetics (n = 437), a well as by race. Results: The 20% adjustment used for AFP appropriately corrects serum values. No such systematic variation is seen for either β-hCG or uE3 by glycemic status or race. Conclusion: No adjustment for β-hCG or uE3 is necessary for diabetes for biochemical screening programs.

KW - Insulin

KW - diabetes

KW - multiple marker biochemical screening

KW - screening programs

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Similarity of insulin-dependent diabetics' and non-insulin-dependent diabetics' levels of β-hCG and unconjugated estriol with controls: No need to adjust as with alpha-fetoprotein

Abstract

Keywords

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