Similarity of insulin-dependent diabetics' and non-insulin-dependent diabetics' levels of β-hCG and unconjugated estriol with controls: No need to adjust as with alpha-fetoprotein

Mark I. Evans, Joseph E. O'Brien, Elena Dvorin, Eric L. Krivchenia, Arie Drugan, Roderick F. Hume, Mark P. Johnson

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Objective: To determine if the same systematic alteration of serum values seen for alpha-fetoprotein (AFP) in diabetic patients is also seen for β- hCG and unconjugated estriol (uE3). Methods: Serum AFP, β-hCG, and uE3 results were obtained in 18,639 patients for whom complete follow-up information was obtained. Patients were divided into euglycemic (n = 18,088), insulin-requiring diabetics (n = 104), and non-insulin-requiring diabetics (n = 437), a well as by race. Results: The 20% adjustment used for AFP appropriately corrects serum values. No such systematic variation is seen for either β-hCG or uE3 by glycemic status or race. Conclusion: No adjustment for β-hCG or uE3 is necessary for diabetes for biochemical screening programs.

Original languageEnglish
Pages (from-to)20-22
Number of pages3
JournalJournal of the Society for Gynecologic Investigation
Volume3
Issue number1
DOIs
StatePublished - Jan 1996
Externally publishedYes

Keywords

  • Insulin
  • diabetes
  • multiple marker biochemical screening
  • screening programs

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