Significant differences when using MDRD for GFR estimation compared to radionuclide measured clearance

A. J. Craig, A. Britten, S. D. Heenan, A. G. Irwin

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Objectives: To evaluate Estimated Glomerular Filtration Rate (eGFR), using the Modification of Diet in Renal Disease equation, and compare with radionuclide GFR (rGFR) in a Radiology setting to assess renal function prior to contrast administration. Methods: Five hundred and sixteen retrospective rGFR studies from a mixed referral population were selected and the eGFR calculated. Regression and Bland-Altman analysis was performed. The percentage of rGFR and eGFR studies below 30 ml/min/1.73 m 2 and 60 ml/min/1.73 m 2 were calculated; these are important thresholds for classifying renal insufficiency. Results: A significant correlation between eGFR and rGFR (R 2=0.62, p<0.0001) and significant differences in the medians (p<0.0001) were found. eGFR overestimated rGFR with a bias (mean difference) of 10.8 ml/min/1.73 m 2 over the whole range of rGFR. Studies with an rGFR of under 30 ml/min/1.73 m 2 had a mean bias of 4.6 ml/min/1.73 m 2 (difference range -5.9 to 26.3 ml/min/1.73 m 2). The bias over the range 30 to 60 ml/min/1.73 m 2 was 13.2 ml/min/1.73 m 2 (difference range -16.8 to 88.3 ml/min/1.73 m 2). In 25.4% of studies, eGFR was less than 60 ml/min/1.73 m 2 compared with 40.5% of rGFR studies. Conclusions: Awareness of the bias between eGFR and rGFR is important when assessing Radiology patients for risks of nephrotoxicity and Nephrogenic Systemic Fibrosis from contrast medium.

Original languageEnglish
Pages (from-to)2211-2217
Number of pages7
JournalEuropean Radiology
Issue number10
StatePublished - Oct 2011
Externally publishedYes


  • Cr-EDTA
  • Gadolinium
  • Glomerular filtration rate
  • MDRD
  • Serum creatinine


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