Significance of EGFR expression in circulating tumor cells

María José Serrano; María Jesús Alvarez-Cubero; Diego de Miguel Pérez; Alba Rodríguez-Martínez; Lucas Gonzalez-Herrera; Inmaculada Robles-Fernandez; José Exposito Hernandez; Jose Luis García Puche; José Antonio Lorente

doi:10.1007/978-3-319-55947-6_16

Significance of EGFR expression in circulating tumor cells

María José Serrano
, María Jesús Alvarez-Cubero
, Diego de Miguel Pérez
, Alba Rodríguez-Martínez
, Lucas Gonzalez-Herrera
, Inmaculada Robles-Fernandez
, José Exposito Hernandez
, Jose Luis García Puche
, José Antonio Lorente

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

9 Scopus citations

Abstract

This chapter focuses on a deep description of the epidermal growth factor receptor (EGFR) expression in circulating tumor cells (CTCs) and its main role in cancer progression, genetic changes related to metastasis, and resistance to treatment. The aberrant behavior of cancer cells is caused by genetic mutations and altered patterns of gene expression. These changes can be responsible for an increase in cell motility but also an ability of CTCs to survival in different microenvironments, as well as developing therapy-resistant clones. Finally, CTCs can acquire the ability to invade distant organs, where metastatic foci can develop.

Original language	English
Title of host publication	Advances in Experimental Medicine and Biology
Publisher	Springer New York LLC
Pages	285-296
Number of pages	12
DOIs	https://doi.org/10.1007/978-3-319-55947-6_16
State	Published - 2017
Externally published	Yes

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	994
ISSN (Print)	0065-2598
ISSN (Electronic)	2214-8019

Keywords

Circulating tumor cells (CTCs)
Dormancy
Epidermal growth factor receptor (EGFR)
Epithelial mesenchymal transition (EMT)
Invasion
Migration
Mutations
Resistant clones

Access to Document

10.1007/978-3-319-55947-6_16

Cite this

Serrano, M. J., Alvarez-Cubero, M. J., de Miguel Pérez, D., Rodríguez-Martínez, A., Gonzalez-Herrera, L., Robles-Fernandez, I., Hernandez, J. E., Puche, J. L. G., & Lorente, J. A. (2017). Significance of EGFR expression in circulating tumor cells. In Advances in Experimental Medicine and Biology (pp. 285-296). (Advances in Experimental Medicine and Biology; Vol. 994). Springer New York LLC. https://doi.org/10.1007/978-3-319-55947-6_16

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title = "Significance of EGFR expression in circulating tumor cells",

abstract = "This chapter focuses on a deep description of the epidermal growth factor receptor (EGFR) expression in circulating tumor cells (CTCs) and its main role in cancer progression, genetic changes related to metastasis, and resistance to treatment. The aberrant behavior of cancer cells is caused by genetic mutations and altered patterns of gene expression. These changes can be responsible for an increase in cell motility but also an ability of CTCs to survival in different microenvironments, as well as developing therapy-resistant clones. Finally, CTCs can acquire the ability to invade distant organs, where metastatic foci can develop.",

keywords = "Circulating tumor cells (CTCs), Dormancy, Epidermal growth factor receptor (EGFR), Epithelial mesenchymal transition (EMT), Invasion, Migration, Mutations, Resistant clones",

author = "Serrano, \{Mar{\'i}a Jos{\'e}\} and Alvarez-Cubero, \{Mar{\'i}a Jes{\'u}s\} and \{de Miguel P{\'e}rez\}, Diego and Alba Rodr{\'i}guez-Mart{\'i}nez and Lucas Gonzalez-Herrera and Inmaculada Robles-Fernandez and Hernandez, \{Jos{\'e} Exposito\} and Puche, \{Jose Luis Garc{\'i}a\} and Lorente, \{Jos{\'e} Antonio\}",

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year = "2017",

doi = "10.1007/978-3-319-55947-6\_16",

language = "English",

series = "Advances in Experimental Medicine and Biology",

publisher = "Springer New York LLC",

pages = "285--296",

booktitle = "Advances in Experimental Medicine and Biology",

}

Serrano, MJ, Alvarez-Cubero, MJ, de Miguel Pérez, D, Rodríguez-Martínez, A, Gonzalez-Herrera, L, Robles-Fernandez, I, Hernandez, JE, Puche, JLG & Lorente, JA 2017, Significance of EGFR expression in circulating tumor cells. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 994, Springer New York LLC, pp. 285-296. https://doi.org/10.1007/978-3-319-55947-6_16

Significance of EGFR expression in circulating tumor cells. / Serrano, María José; Alvarez-Cubero, María Jesús; de Miguel Pérez, Diego et al.
Advances in Experimental Medicine and Biology. Springer New York LLC, 2017. p. 285-296 (Advances in Experimental Medicine and Biology; Vol. 994).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

TY - CHAP

T1 - Significance of EGFR expression in circulating tumor cells

AU - Serrano, María José

AU - Alvarez-Cubero, María Jesús

AU - de Miguel Pérez, Diego

AU - Rodríguez-Martínez, Alba

AU - Gonzalez-Herrera, Lucas

AU - Robles-Fernandez, Inmaculada

AU - Hernandez, José Exposito

AU - Puche, Jose Luis García

AU - Lorente, José Antonio

N1 - Publisher Copyright: © Springer International Publishing AG 2017.

PY - 2017

Y1 - 2017

N2 - This chapter focuses on a deep description of the epidermal growth factor receptor (EGFR) expression in circulating tumor cells (CTCs) and its main role in cancer progression, genetic changes related to metastasis, and resistance to treatment. The aberrant behavior of cancer cells is caused by genetic mutations and altered patterns of gene expression. These changes can be responsible for an increase in cell motility but also an ability of CTCs to survival in different microenvironments, as well as developing therapy-resistant clones. Finally, CTCs can acquire the ability to invade distant organs, where metastatic foci can develop.

AB - This chapter focuses on a deep description of the epidermal growth factor receptor (EGFR) expression in circulating tumor cells (CTCs) and its main role in cancer progression, genetic changes related to metastasis, and resistance to treatment. The aberrant behavior of cancer cells is caused by genetic mutations and altered patterns of gene expression. These changes can be responsible for an increase in cell motility but also an ability of CTCs to survival in different microenvironments, as well as developing therapy-resistant clones. Finally, CTCs can acquire the ability to invade distant organs, where metastatic foci can develop.

KW - Circulating tumor cells (CTCs)

KW - Dormancy

KW - Epidermal growth factor receptor (EGFR)

KW - Epithelial mesenchymal transition (EMT)

KW - Invasion

KW - Migration

KW - Mutations

KW - Resistant clones

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T3 - Advances in Experimental Medicine and Biology

SP - 285

EP - 296

BT - Advances in Experimental Medicine and Biology

PB - Springer New York LLC

ER -

Significance of EGFR expression in circulating tumor cells

Abstract

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Keywords

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