TY - JOUR
T1 - Significance of DNA content abnormalities in small rectal cancers
AU - Heimann, Tomas M.
AU - Miller, Felice
AU - Martinelli, Giorgio
AU - Mester, Jolinda
AU - Kurtz, Robert J.
AU - Szporn, Arnold
AU - Fasy, Thomas
PY - 1990/2
Y1 - 1990/2
N2 - Several studies have shown that the presence of DNA content abnormalities, measured by flow cytometry, may correlate with a poor prognosis in a variety of cancers. The predictive value of DNA content in patients with small rectal cancers has not been well determined. Thirty-nine patients with primary rectal adenocarcinoma smaller than 3 cm were studied in a comparison of DNA content with established prognostic variables. The following covariates were evaluated for their prognostic value: sex, age, tumor size, location, distal margin, Dukes' classification, tumor differentiation, and DNA content. DNA content was assessed by flow cytometric analysis, and each tumor was categorized as diploid or nondiploid. Of the parameters studied, Dukes' classification and tumor DNA content were found to be independent prognostic indicators. Determination of DNA content seems to provide additional useful prognostic information in patients with small rectal tumors.
AB - Several studies have shown that the presence of DNA content abnormalities, measured by flow cytometry, may correlate with a poor prognosis in a variety of cancers. The predictive value of DNA content in patients with small rectal cancers has not been well determined. Thirty-nine patients with primary rectal adenocarcinoma smaller than 3 cm were studied in a comparison of DNA content with established prognostic variables. The following covariates were evaluated for their prognostic value: sex, age, tumor size, location, distal margin, Dukes' classification, tumor differentiation, and DNA content. DNA content was assessed by flow cytometric analysis, and each tumor was categorized as diploid or nondiploid. Of the parameters studied, Dukes' classification and tumor DNA content were found to be independent prognostic indicators. Determination of DNA content seems to provide additional useful prognostic information in patients with small rectal tumors.
UR - http://www.scopus.com/inward/record.url?scp=0025095371&partnerID=8YFLogxK
U2 - 10.1016/S0002-9610(05)80259-4
DO - 10.1016/S0002-9610(05)80259-4
M3 - Article
C2 - 2301713
AN - SCOPUS:0025095371
SN - 0002-9610
VL - 159
SP - 199
EP - 202
JO - American Journal of Surgery
JF - American Journal of Surgery
IS - 2
ER -