Signaling mechanisms implicated in cranial sutures pathophysiology: Craniosynostosis

Maria A. Katsianou, Christos Adamopoulos, Heleni Vastardis, Efthimia K. Basdra

Research output: Contribution to journalReview articlepeer-review

53 Scopus citations

Abstract

Normal extension and skull expansion is a synchronized process that prevails along the osteogenic intersections of the cranial sutures. Cranial sutures operate as bone growth sites allowing swift bone generation at the edges of the bone fronts while they remain patent. Premature fusion of one or more cranial sutures can trigger craniosynostosis, a birth defect characterized by dramatic manifestations in appearance and functional impairment. Up until today, surgical correction is the only restorative measure for craniosynostosis associated with considerable mortality. Clinical studies have identified several genes implicated in the pathogenesis of craniosynostosis syndromes with useful insights into the underlying molecular signaling events that determine suture fate. In this review, we exploit the intracellular signal transduction pathways implicated in suture pathobiology, in an attempt to identify key signaling molecules for therapeutic targeting.

Original languageEnglish
Pages (from-to)165-176
Number of pages12
JournalBBA Clinical
Volume6
DOIs
StatePublished - 1 Dec 2016
Externally publishedYes

Keywords

  • Craniosynostosis
  • Craniosynostosis therapies
  • Mechanical stimuli
  • Molecular signaling
  • Polycystins
  • Sutures

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