Signaling by dual specificity kinases

N. Dhanasekaran, E. Premkumar Reddy

Research output: Contribution to journalReview articlepeer-review

268 Scopus citations

Abstract

Dual specificity kinases that phosphorylate the Thr- and Tyr-residues within the TXY motif of MAP-kinases of play a central role in the regulation of various processes of cell growth. These dual specificity kinases also known as MAP kinase kinases are constituents of the sequential kinase signaling modules. Seven distinct mammalian MAP kinases kinases have been identified. Some of the unique signaling properties of these kinases are discussed here.

Original languageEnglish
Pages (from-to)1447-1455
Number of pages9
JournalOncogene
Volume17
Issue number11 REV. ISS. 1
DOIs
StatePublished - 17 Sep 1998
Externally publishedYes

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