Signal recognition and integration by GS-stimulated adenylyl cyclases

Joseph P. Pieroni; Ofer Jacobowitz; Jianqiang Chen; Ravi lyengar

doi:10.1016/0959-4388(93)90127-K

Signal recognition and integration by G_S-stimulated adenylyl cyclases

Joseph P. Pieroni, Ofer Jacobowitz, Jianqiang Chen, Ravi lyengar

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Six G_s stimulated adenylyl cyclases have been cloned. Two additional forms have been identified as partial cDNAs. These adenylyl cyclases have distinct functional properties and are differentially regulated by protein kinases. The adenylyl cyclases have distinct patterns of distribution in peripheral tissues and various brain regions. The unique functional characteristics of the members of this effector family may allow each cell type and/or brain region to customize the signal-recognition and integrative properties of its cAMP-generation system by varying the ratios of the various adenylyl cyclases.

Original language	English
Pages (from-to)	345-351
Number of pages	7
Journal	Current Opinion in Neurobiology
Volume	3
Issue number	3
DOIs	https://doi.org/10.1016/0959-4388(93)90127-K
State	Published - Jun 1993

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title = "Signal recognition and integration by GS-stimulated adenylyl cyclases",

abstract = "Six Gs stimulated adenylyl cyclases have been cloned. Two additional forms have been identified as partial cDNAs. These adenylyl cyclases have distinct functional properties and are differentially regulated by protein kinases. The adenylyl cyclases have distinct patterns of distribution in peripheral tissues and various brain regions. The unique functional characteristics of the members of this effector family may allow each cell type and/or brain region to customize the signal-recognition and integrative properties of its cAMP-generation system by varying the ratios of the various adenylyl cyclases.",

author = "Pieroni, {Joseph P.} and Ofer Jacobowitz and Jianqiang Chen and Ravi lyengar",

note = "Funding Information: Research in our laboratoty is supportedb y NIH grants CA-44998 and DK-38761, and American Cancer Society grant CD-518. We thank Drs H Bourne and D Cooper for preprints and Dr W Clarke for helpful discussions.",

year = "1993",

month = jun,

doi = "10.1016/0959-4388(93)90127-K",

language = "English",

volume = "3",

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journal = "Current Opinion in Neurobiology",

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T1 - Signal recognition and integration by GS-stimulated adenylyl cyclases

AU - Pieroni, Joseph P.

AU - Jacobowitz, Ofer

AU - Chen, Jianqiang

AU - lyengar, Ravi

N1 - Funding Information: Research in our laboratoty is supportedb y NIH grants CA-44998 and DK-38761, and American Cancer Society grant CD-518. We thank Drs H Bourne and D Cooper for preprints and Dr W Clarke for helpful discussions.

PY - 1993/6

Y1 - 1993/6

N2 - Six Gs stimulated adenylyl cyclases have been cloned. Two additional forms have been identified as partial cDNAs. These adenylyl cyclases have distinct functional properties and are differentially regulated by protein kinases. The adenylyl cyclases have distinct patterns of distribution in peripheral tissues and various brain regions. The unique functional characteristics of the members of this effector family may allow each cell type and/or brain region to customize the signal-recognition and integrative properties of its cAMP-generation system by varying the ratios of the various adenylyl cyclases.

AB - Six Gs stimulated adenylyl cyclases have been cloned. Two additional forms have been identified as partial cDNAs. These adenylyl cyclases have distinct functional properties and are differentially regulated by protein kinases. The adenylyl cyclases have distinct patterns of distribution in peripheral tissues and various brain regions. The unique functional characteristics of the members of this effector family may allow each cell type and/or brain region to customize the signal-recognition and integrative properties of its cAMP-generation system by varying the ratios of the various adenylyl cyclases.

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JF - Current Opinion in Neurobiology

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Signal recognition and integration by GS-stimulated adenylyl cyclases

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Signal recognition and integration by G_S-stimulated adenylyl cyclases