Shrink-film configurable multiscale wrinkles for functional alignment of human embryonic stem cells and their cardiac derivatives

Aaron Chen; Deborah K. Lieu; Lauren Freschauf; Valerie Lew; Himanshu Sharma; Jiaxian Wang; Diep Nguyen; Ioannis Karakikes; Roger J. Hajjar; Ajay Gopinathan; Elliot Botvinick; Charless C. Fowlkes; Ronald A. Li; Michelle Khine

doi:10.1002/adma.201103463

Shrink-film configurable multiscale wrinkles for functional alignment of human embryonic stem cells and their cardiac derivatives

Aaron Chen
, Deborah K. Lieu
, Lauren Freschauf
, Valerie Lew
, Himanshu Sharma
, Jiaxian Wang
, Diep Nguyen
, Ioannis Karakikes
, Roger J. Hajjar
, Ajay Gopinathan
, Elliot Botvinick
, Charless C. Fowlkes
, Ronald A. Li
, Michelle Khine

Research output: Contribution to journal › Article › peer-review

117 Scopus citations

Abstract

A biomimetic substrate for cell-culture is fabricated by plasma treatment of a prestressed thermoplastic shrink film to create tunable multiscaled alignment "wrinkles". Using this substrate, the functional alignment of human embryonic stem cell derived cardiomyocytes is demonstrated.

Original language	English
Pages (from-to)	5785-5791
Number of pages	7
Journal	Advanced Materials
Volume	23
Issue number	48
DOIs	https://doi.org/10.1002/adma.201103463
State	Published - 22 Dec 2011

Keywords

action potential propagation
biomimetics
contact guidance
human embryonic stem cell derived cardiomyocytes

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10.1002/adma.201103463

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Chen, A., Lieu, D. K., Freschauf, L., Lew, V., Sharma, H., Wang, J., Nguyen, D., Karakikes, I., Hajjar, R. J., Gopinathan, A., Botvinick, E., Fowlkes, C. C., Li, R. A., & Khine, M. (2011). Shrink-film configurable multiscale wrinkles for functional alignment of human embryonic stem cells and their cardiac derivatives. Advanced Materials, 23(48), 5785-5791. https://doi.org/10.1002/adma.201103463

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title = "Shrink-film configurable multiscale wrinkles for functional alignment of human embryonic stem cells and their cardiac derivatives",

abstract = "A biomimetic substrate for cell-culture is fabricated by plasma treatment of a prestressed thermoplastic shrink film to create tunable multiscaled alignment {"}wrinkles{"}. Using this substrate, the functional alignment of human embryonic stem cell derived cardiomyocytes is demonstrated.",

keywords = "action potential propagation, biomimetics, contact guidance, human embryonic stem cell derived cardiomyocytes",

author = "Aaron Chen and Lieu, \{Deborah K.\} and Lauren Freschauf and Valerie Lew and Himanshu Sharma and Jiaxian Wang and Diep Nguyen and Ioannis Karakikes and Hajjar, \{Roger J.\} and Ajay Gopinathan and Elliot Botvinick and Fowlkes, \{Charless C.\} and Li, \{Ronald A.\} and Michelle Khine",

year = "2011",

month = dec,

day = "22",

doi = "10.1002/adma.201103463",

language = "English",

volume = "23",

pages = "5785--5791",

journal = "Advanced Materials",

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Chen, A, Lieu, DK, Freschauf, L, Lew, V, Sharma, H, Wang, J, Nguyen, D, Karakikes, I, Hajjar, RJ, Gopinathan, A, Botvinick, E, Fowlkes, CC, Li, RA & Khine, M 2011, 'Shrink-film configurable multiscale wrinkles for functional alignment of human embryonic stem cells and their cardiac derivatives', Advanced Materials, vol. 23, no. 48, pp. 5785-5791. https://doi.org/10.1002/adma.201103463

TY - JOUR

T1 - Shrink-film configurable multiscale wrinkles for functional alignment of human embryonic stem cells and their cardiac derivatives

AU - Chen, Aaron

AU - Lieu, Deborah K.

AU - Freschauf, Lauren

AU - Lew, Valerie

AU - Sharma, Himanshu

AU - Wang, Jiaxian

AU - Nguyen, Diep

AU - Karakikes, Ioannis

AU - Hajjar, Roger J.

AU - Gopinathan, Ajay

AU - Botvinick, Elliot

AU - Fowlkes, Charless C.

AU - Li, Ronald A.

AU - Khine, Michelle

PY - 2011/12/22

Y1 - 2011/12/22

N2 - A biomimetic substrate for cell-culture is fabricated by plasma treatment of a prestressed thermoplastic shrink film to create tunable multiscaled alignment "wrinkles". Using this substrate, the functional alignment of human embryonic stem cell derived cardiomyocytes is demonstrated.

AB - A biomimetic substrate for cell-culture is fabricated by plasma treatment of a prestressed thermoplastic shrink film to create tunable multiscaled alignment "wrinkles". Using this substrate, the functional alignment of human embryonic stem cell derived cardiomyocytes is demonstrated.

KW - action potential propagation

KW - biomimetics

KW - contact guidance

KW - human embryonic stem cell derived cardiomyocytes

UR - https://www.scopus.com/pages/publications/83755163641

U2 - 10.1002/adma.201103463

DO - 10.1002/adma.201103463

M3 - Article

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AN - SCOPUS:83755163641

SN - 0935-9648

VL - 23

SP - 5785

EP - 5791

JO - Advanced Materials

JF - Advanced Materials

IS - 48

ER -

Shrink-film configurable multiscale wrinkles for functional alignment of human embryonic stem cells and their cardiac derivatives

Abstract

Keywords

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