TY - JOUR
T1 - Short sleep duration and type 2 diabetes enhance the risk of cardiovascular events in hypertensive patients
AU - Eguchi, Kazuo
AU - Hoshide, Satoshi
AU - Ishikawa, Shizukiyo
AU - Shimada, Kazuyuki
AU - Kario, Kazuomi
N1 - Funding Information:
The authors acknowledge the support of grants-in-aid (1998–1999, 2001–2002, 2004–2005) from the Foundation for the Development of the Community, Tochigi, Japan . The authors thank Prof. Joseph E. Schwartz for the statistical assistance.
PY - 2012/12
Y1 - 2012/12
N2 - Aims: We tested the hypothesis that short sleep duration is not only a risk factor for diabetes, but that the two conditions in combination would be associated with the risk of incident cardiovascular disease (CVD). Methods: We analyzed 1255 hypertensive patients (mean age: 70.4. ±. 9.9 years) with (N=. 299) and without diabetes (N=. 956). Short sleep duration was defined as a sleep time <7.5. h. A Hard CVD event was defined as either myocardial infarction, stroke, or sudden cardiac death; and All CVD events as Hard CVD events plus angina, heart failure and end-stage renal disease. Results: When the patients were divided into 4 categories by diabetes (present or absent) and sleep duration (short or long), the diabetes. +. short sleep group had a significantly higher incidence of both Hard CVD events (HR = 2.27, 95% CI = 1.17-4.42, P=. 0.015) and All CVD events (HR = 2.47, 95% CI = 1.37-4.43, P=. 0.003) compared with the non-diabetes. +. long sleep group, independent of significant covariates. There were significant interactions between sleep duration and glycemic control on CVD events. Conclusions: The combination of both diabetes and short duration of sleep was associated with higher risk of incident CVD compared with those with only one or neither condition. Altered glycemic control and short sleep duration could act synergistically to pose a risk for future CVD.
AB - Aims: We tested the hypothesis that short sleep duration is not only a risk factor for diabetes, but that the two conditions in combination would be associated with the risk of incident cardiovascular disease (CVD). Methods: We analyzed 1255 hypertensive patients (mean age: 70.4. ±. 9.9 years) with (N=. 299) and without diabetes (N=. 956). Short sleep duration was defined as a sleep time <7.5. h. A Hard CVD event was defined as either myocardial infarction, stroke, or sudden cardiac death; and All CVD events as Hard CVD events plus angina, heart failure and end-stage renal disease. Results: When the patients were divided into 4 categories by diabetes (present or absent) and sleep duration (short or long), the diabetes. +. short sleep group had a significantly higher incidence of both Hard CVD events (HR = 2.27, 95% CI = 1.17-4.42, P=. 0.015) and All CVD events (HR = 2.47, 95% CI = 1.37-4.43, P=. 0.003) compared with the non-diabetes. +. long sleep group, independent of significant covariates. There were significant interactions between sleep duration and glycemic control on CVD events. Conclusions: The combination of both diabetes and short duration of sleep was associated with higher risk of incident CVD compared with those with only one or neither condition. Altered glycemic control and short sleep duration could act synergistically to pose a risk for future CVD.
KW - Cardiovascular disease
KW - Diabetes
KW - Glycemic control
KW - Interaction
KW - Sleep duration
UR - http://www.scopus.com/inward/record.url?scp=84870663967&partnerID=8YFLogxK
U2 - 10.1016/j.diabres.2012.09.014
DO - 10.1016/j.diabres.2012.09.014
M3 - Article
C2 - 23020940
AN - SCOPUS:84870663967
SN - 0168-8227
VL - 98
SP - 518
EP - 523
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
IS - 3
ER -