Short course prophylactic cranial irradiation for small cell lung cancer

R. Feld, G. H. Clamon, R. Blum, E. Moran, R. Weiner, B. Kramer, W. K. Evans, J. G. Herman, F. Hoffman, L. Burmeister

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Ninety-one patients with small cell carcinoma of the lung were given a shortened, intensive course of prophylactic cranial irradiation consisting of 2,000 rad in five fractions. The CNS relapse rate was 21%, but in only one of 91 patients was the brain the first and only site of relapse. Acute toxicities consisting of headache (16%) and nausea and vomiting (15%) were observed. Results are compared with previous results from other studies of cranial irradiation.

Original languageEnglish
Pages (from-to)371-376
Number of pages6
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Issue number5
StatePublished - 1985
Externally publishedYes


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