Short communication: No evidence of HTLV-3 and HTLV-4 infection in New York State subjects at risk for retroviral infection

Raisa Perzova, Patricia Benz, Lynn Abbott, Caitlin Welch, Anish Thomas, Rawad El Ghoul, Swathi Sanghi, Peter Nara, Jordon Glaser, Frederick P. Siegal, Harvey Dosik, Bernard J. Poiesz

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The primate T-cell lymphoma viruses (PTLV) are divided into six distinct species. The biology and epidemiology of PTLV-1 and PTLV-2 are very well understood. However, that of PTLV-3, 4, 5, and 6 are not. Recently, in Cameroon, three and one humans were shown to be infected with HTLV-3 and HTLV-4, respectively. We undertook a study to ascertain whether any of these two retroviruses were present in the peripheral blood mononuclear cell DNA of New York State subjects deemed at risk for PTLV infection. Samples were analyzed by PTLV-3 and PTLV-4 specific PCR assays from the following human and simian subject types: African-American medical clinic patients; HTLV EIA+, WB indeterminate blood donors; intravenous drug users; patients with leukemia, lymphoma, myelopathy, polymyositis, or AIDS; and African chimpanzees. None of the 1200 subjects was positive for HTLV-3 or 4. The data indicate that, at the time of sample collection, no evidence exists for the dissemination of HTLV-3 or 4 to New York State. Continued epidemiological studies are warranted to explore the worldwide prevalence rates and dissemination patterns of HTLV-3 and 4 infections, and their possible disease associations.

Original languageEnglish
Pages (from-to)1229-1231
Number of pages3
JournalAIDS Research and Human Retroviruses
Volume26
Issue number11
DOIs
StatePublished - 1 Nov 2010
Externally publishedYes

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