Short Communication: Manα1-2Man-Binding Anti-HIV Lectins Enhance the Exposure of V2i and V3 Crown Neutralization Epitopes on the V1/V2 and V3 Hypervariable Loops of HIV-1 Envelope

Muzafar Jan, Chitra Upadhyay, Aman Sharma, Catarina E. Hioe, Sunil K. Arora

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

This study aimed to explore the contribution of high-mannose glycans in the masking of conserved V3 crown (GPG) and V2i epitopes on the hypervariable loops of most exposed distal surface of HIV-1 Env. Using lectins specific to Mana1-2Man residue containing Man6-9GlcNAc2 glycans extensively decorating HIV-1 Env, we found that Mana1-2Man-binding lectins enhance the exposure of these partially and transiently exposed epitopes and consequentially increase the neutralization strength of antibodies against these epitopes.

Original languageEnglish
Pages (from-to)941-945
Number of pages5
JournalAIDS Research and Human Retroviruses
Volume33
Issue number9
DOIs
StatePublished - Sep 2017

Keywords

  • HIV-1
  • N-linked glycans
  • anti-HIV lectins
  • envelope
  • hypervariable loop epitopes

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