Short communication: Diffusion tensor anisotropy in the cingulate in borderline and schizotypal personality disorder

Kim E. Goldstein, M. Mehmet Haznedar, Lauren B. Alloy, Deborah A.G. Drabick, Margaret M. McClure, Antonia S. New, King Wai Chu, Daniel Vaccaro, Cheuk Y. Tang, David Meyerson, Erin A. Hazlett

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Despite considerable phenomentological differences between borderline personality disorder (BPD) and schizotypal personality disorder (SPD), research increasingly provides evidence that some BPD symptoms overlap with SPD symptoms (e.g., disturbed cognitions). We examined the cingulate, a brain region implicated in the pathophysiology of both disorders, to determine similarities/differences between the groups, and similarities/differences from healthy controls (HC's). 3T structural and diffusion tensor magnetic resonance imaging scans were acquired in BPD (n = 27), SPD (n = 32), HC's (n = 34). Results revealed that BPD patients exhibited significantly lower FA in posterior cingulate white matter compared to HC's (p = 0.04), but SPD patients did not.

Original languageEnglish
Pages (from-to)353-357
Number of pages5
JournalPsychiatry Research
Volume279
DOIs
StatePublished - Sep 2019

Keywords

  • Borderline personality disorder
  • Diffusion tensor imaging
  • Schizotypal personality disorder

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