Short communication: Diffusion tensor anisotropy in the cingulate in borderline and schizotypal personality disorder

Kim E. Goldstein; M. Mehmet Haznedar; Lauren B. Alloy; Deborah A.G. Drabick; Margaret M. McClure; Antonia S. New; King Wai Chu; Daniel Vaccaro; Cheuk Y. Tang; David Meyerson; Erin A. Hazlett

doi:10.1016/j.psychres.2019.05.016

Short communication: Diffusion tensor anisotropy in the cingulate in borderline and schizotypal personality disorder

Kim E. Goldstein, M. Mehmet Haznedar, Lauren B. Alloy, Deborah A.G. Drabick, Margaret M. McClure, Antonia S. New, King Wai Chu, Daniel Vaccaro, Cheuk Y. Tang, David Meyerson, Erin A. Hazlett

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Despite considerable phenomentological differences between borderline personality disorder (BPD) and schizotypal personality disorder (SPD), research increasingly provides evidence that some BPD symptoms overlap with SPD symptoms (e.g., disturbed cognitions). We examined the cingulate, a brain region implicated in the pathophysiology of both disorders, to determine similarities/differences between the groups, and similarities/differences from healthy controls (HC's). 3T structural and diffusion tensor magnetic resonance imaging scans were acquired in BPD (n = 27), SPD (n = 32), HC's (n = 34). Results revealed that BPD patients exhibited significantly lower FA in posterior cingulate white matter compared to HC's (p = 0.04), but SPD patients did not.

Original language	English
Pages (from-to)	353-357
Number of pages	5
Journal	Psychiatry Research
Volume	279
DOIs	https://doi.org/10.1016/j.psychres.2019.05.016
State	Published - Sep 2019

Keywords

Borderline personality disorder
Diffusion tensor imaging
Schizotypal personality disorder

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10.1016/j.psychres.2019.05.016

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Goldstein, K. E., Haznedar, M. M., Alloy, L. B., Drabick, D. A. G., McClure, M. M., New, A. S., Chu, K. W., Vaccaro, D., Tang, C. Y., Meyerson, D., & Hazlett, E. A. (2019). Short communication: Diffusion tensor anisotropy in the cingulate in borderline and schizotypal personality disorder. Psychiatry Research, 279, 353-357. https://doi.org/10.1016/j.psychres.2019.05.016

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title = "Short communication: Diffusion tensor anisotropy in the cingulate in borderline and schizotypal personality disorder",

abstract = "Despite considerable phenomentological differences between borderline personality disorder (BPD) and schizotypal personality disorder (SPD), research increasingly provides evidence that some BPD symptoms overlap with SPD symptoms (e.g., disturbed cognitions). We examined the cingulate, a brain region implicated in the pathophysiology of both disorders, to determine similarities/differences between the groups, and similarities/differences from healthy controls (HC's). 3T structural and diffusion tensor magnetic resonance imaging scans were acquired in BPD (n = 27), SPD (n = 32), HC's (n = 34). Results revealed that BPD patients exhibited significantly lower FA in posterior cingulate white matter compared to HC's (p = 0.04), but SPD patients did not.",

keywords = "Borderline personality disorder, Diffusion tensor imaging, Schizotypal personality disorder",

author = "Goldstein, {Kim E.} and Haznedar, {M. Mehmet} and Alloy, {Lauren B.} and Drabick, {Deborah A.G.} and McClure, {Margaret M.} and New, {Antonia S.} and Chu, {King Wai} and Daniel Vaccaro and Tang, {Cheuk Y.} and David Meyerson and Hazlett, {Erin A.}",

note = "Funding Information: This work was supported by NIMH grant R01MH073911 and a VA Research Career Scientist Award (1 IK6 CX001738-01) to Dr. Hazlett. Partial support also came from CTSA grant UL1TR000067 from the National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health (NIH). None of the authors have any conflicts of interest. Publisher Copyright: {\textcopyright} 2019",

year = "2019",

month = sep,

doi = "10.1016/j.psychres.2019.05.016",

language = "English",

volume = "279",

pages = "353--357",

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AU - Goldstein, Kim E.

AU - Haznedar, M. Mehmet

AU - Alloy, Lauren B.

AU - Drabick, Deborah A.G.

AU - McClure, Margaret M.

AU - New, Antonia S.

AU - Chu, King Wai

AU - Vaccaro, Daniel

AU - Tang, Cheuk Y.

AU - Meyerson, David

AU - Hazlett, Erin A.

N1 - Funding Information: This work was supported by NIMH grant R01MH073911 and a VA Research Career Scientist Award (1 IK6 CX001738-01) to Dr. Hazlett. Partial support also came from CTSA grant UL1TR000067 from the National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health (NIH). None of the authors have any conflicts of interest. Publisher Copyright: © 2019

PY - 2019/9

Y1 - 2019/9

N2 - Despite considerable phenomentological differences between borderline personality disorder (BPD) and schizotypal personality disorder (SPD), research increasingly provides evidence that some BPD symptoms overlap with SPD symptoms (e.g., disturbed cognitions). We examined the cingulate, a brain region implicated in the pathophysiology of both disorders, to determine similarities/differences between the groups, and similarities/differences from healthy controls (HC's). 3T structural and diffusion tensor magnetic resonance imaging scans were acquired in BPD (n = 27), SPD (n = 32), HC's (n = 34). Results revealed that BPD patients exhibited significantly lower FA in posterior cingulate white matter compared to HC's (p = 0.04), but SPD patients did not.

AB - Despite considerable phenomentological differences between borderline personality disorder (BPD) and schizotypal personality disorder (SPD), research increasingly provides evidence that some BPD symptoms overlap with SPD symptoms (e.g., disturbed cognitions). We examined the cingulate, a brain region implicated in the pathophysiology of both disorders, to determine similarities/differences between the groups, and similarities/differences from healthy controls (HC's). 3T structural and diffusion tensor magnetic resonance imaging scans were acquired in BPD (n = 27), SPD (n = 32), HC's (n = 34). Results revealed that BPD patients exhibited significantly lower FA in posterior cingulate white matter compared to HC's (p = 0.04), but SPD patients did not.

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Short communication: Diffusion tensor anisotropy in the cingulate in borderline and schizotypal personality disorder

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