Short-circuit current related to active transport of chloride in frog cornea: effects of furosemide and ethacrynic acid

Oscar A. Candia

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53 Scopus citations

Abstract

Active transport of Cl- accounts for 90% of the short-circuit current (s.c.c.) in the isolated frog cornea. 1·10-5 M furosemide produced a 50% reversible inhibition of this s.c.c. 1·10-4 M ethacrynic acid reduced the corneal s.c.c. to 32% of the control. In the isolated frog skin epithelium furosemide had no effect on the s.c. at a concentration of 1·10-4 M and a small stimulation at a concentration of 1·10-3 M. The furosemide inhibitory effects seems to be specific for Cl-, as it also inhibits Cl- transport in the ascending limb of the loop of Henle (Burg, M.B. (1972) Proc. 5th Int. Congr. Nephrol., p. 50, Abstr.).

Original languageEnglish
Pages (from-to)1011-1014
Number of pages4
JournalBiochimica et Biophysica Acta - Biomembranes
Volume298
Issue number4
DOIs
StatePublished - 16 Apr 1973
Externally publishedYes

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