TY - JOUR
T1 - Shedding light on proteolytic cleavage of CD44
T2 - The responsible sheddase and functional significance of shedding
AU - Stamenkovic, Ivan
AU - Yu, Qin
N1 - Funding Information:
We are grateful for support from the Swiss National Scientific Research Foundation and the Molecular Oncology National Center of Competence in Research (to IS) and from the Department of Defense–US Army Medical Research (W81XWH-05-1-0191 to QY) and the National Cancer Institute, National Institutes of Health (R01CA116510 to QY).
PY - 2009/6
Y1 - 2009/6
N2 - CD44 is the major cell-surface receptor for hyaluronan, which is implicated in cell-cell and cell-matrix adhesion, cell migration, and signaling. Studies have shown that CD44-dependent migration requires CD44 to be shed from the cell surface and that matrix metalloproteinase-mediated cleavage may provide an underlying mechanism. However, the full spectrum of proteases that may participate in CD44 shedding has yet to be defined. In this issue, Anderegg et al. demonstrate that ADAM10, but not ADAM17 or MMP14, mediates constitutive shedding of CD44 in human melanoma cells and that knockdown of ADAM10 blocks the antiproliferative activity of the soluble proteolytic cleavage product of CD44.
AB - CD44 is the major cell-surface receptor for hyaluronan, which is implicated in cell-cell and cell-matrix adhesion, cell migration, and signaling. Studies have shown that CD44-dependent migration requires CD44 to be shed from the cell surface and that matrix metalloproteinase-mediated cleavage may provide an underlying mechanism. However, the full spectrum of proteases that may participate in CD44 shedding has yet to be defined. In this issue, Anderegg et al. demonstrate that ADAM10, but not ADAM17 or MMP14, mediates constitutive shedding of CD44 in human melanoma cells and that knockdown of ADAM10 blocks the antiproliferative activity of the soluble proteolytic cleavage product of CD44.
UR - http://www.scopus.com/inward/record.url?scp=66149126456&partnerID=8YFLogxK
U2 - 10.1038/jid.2009.13
DO - 10.1038/jid.2009.13
M3 - Comment/debate
C2 - 19434087
AN - SCOPUS:66149126456
SN - 0022-202X
VL - 129
SP - 1321
EP - 1324
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 6
ER -