Shedding light on proteolytic cleavage of CD44: The responsible sheddase and functional significance of shedding

Ivan Stamenkovic, Qin Yu

Research output: Contribution to journalComment/debate

45 Scopus citations

Abstract

CD44 is the major cell-surface receptor for hyaluronan, which is implicated in cell-cell and cell-matrix adhesion, cell migration, and signaling. Studies have shown that CD44-dependent migration requires CD44 to be shed from the cell surface and that matrix metalloproteinase-mediated cleavage may provide an underlying mechanism. However, the full spectrum of proteases that may participate in CD44 shedding has yet to be defined. In this issue, Anderegg et al. demonstrate that ADAM10, but not ADAM17 or MMP14, mediates constitutive shedding of CD44 in human melanoma cells and that knockdown of ADAM10 blocks the antiproliferative activity of the soluble proteolytic cleavage product of CD44.

Original languageEnglish
Pages (from-to)1321-1324
Number of pages4
JournalJournal of Investigative Dermatology
Volume129
Issue number6
DOIs
StatePublished - Jun 2009

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