Shedding light on key pharmacological knowledge and strategies for pediatric atopic dermatitis

Ariana Moreno, Yael Renert-Yuval, Emma Guttman-Yassky

Research output: Contribution to journalReview articlepeer-review


Introduction: Atopic dermatitis (AD) is an inflammatory disease affecting over 20% of the pediatric population, with 85% of cases presenting before the age of five. Recently, therapeutic options in pediatric patients have evolved rapidly, following extensive development in adult treatments. Areas covered: This review will encompass relevant molecular drivers, along with an overlook on treatment modalities in pediatric AD, as well as a summary of pipeline treatments in clinical trials for pediatric patients from PubMed, Google Scholar, and up to July 2022. Topical corticosteroids are the mainstay for AD flares in adults and children. Topical approved agents in pediatric AD are calcineurin inhibitors, crisaborolecrisaborole, and ruxolitinib. Dupilumab is the only FDA approved biologic for patients with AD from six months of age. A Janus kinase inhibitor, upadacitinib, is a systemic treatment approved for pediatric AD patients (age >12 years). Systemic immunosuppressants used in pediatric AD include methotrexate, azathioprine, cyclosporinecyclosporine, and mycophenolate mofetil. Expert opinion: Data regarding disease prevention are conflicting, however, an abundance of research has transpired regarding amelioration of symptoms and induction of disease clearance by targeting numerous pathological mechanisms. Understanding the pediatric AD phenotype will further advance the field and the development of improved therapeutics.

Original languageEnglish
Pages (from-to)119-131
Number of pages13
JournalExpert Review of Clinical Pharmacology
Issue number2
StatePublished - 2023


  • Atopic dermatitis
  • azathioprine
  • calcineurin inhibitors
  • crisaborole
  • dupilumab
  • eczema
  • janus kinase inhibitor
  • methotrexate
  • mycophenolate mofetil
  • pediatric
  • systemics
  • topical corticosteroids


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