Shear wave elastography in the detection of sinusoidal obstruction syndrome in adult patients undergoing allogenic hematopoietic stem cell transplantation

Marten Schulz; Lam Giang Vuong; Hans Peter Müller; Martin Maibier; Frank Tacke; Igor Wolfgang Blau; Alexander Wree

doi:10.3390/diagnostics11060928

Shear wave elastography in the detection of sinusoidal obstruction syndrome in adult patients undergoing allogenic hematopoietic stem cell transplantation

Marten Schulz, Lam Giang Vuong, Hans Peter Müller, Martin Maibier, Frank Tacke, Igor Wolfgang Blau, Alexander Wree

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Hepatic sinusoidal obstruction syndrome (SOS), also known as veno-occlusive disease (VOD) can be a life-threatening complication after hematopoietic stem cell transplantation (HSCT). Diagnosis is often difficult and traditionally based on clinical parameters. Shear wave elastography (SWE) is a modern non-invasive liver stiffness measurement technique using ultrasound. In this monocentric study, we evaluated the role of SWE in diagnosing SOS/VOD in 63 adult patients undergoing HSCT from February 2020 to August 2020 in real world settings. Three patients devel-oped SOS/VOD. This was accompanied by an increase in shear wave velocity in all three patients, indicating that this method may contribute to establishing the diagnosis SOS/VOD after HSCT.

Original language	English
Article number	928
Journal	Diagnostics
Volume	11
Issue number	6
DOIs	https://doi.org/10.3390/diagnostics11060928
State	Published - Jun 2021
Externally published	Yes

Keywords

Hematopoietic stem cell transplantation (HSCT)
Liver stiffness measurement (LSM)
Shear wave elastography (SWE)
Sinusoidal obstruction syndrome (SOS)
Veno-occlusive disease (VOD)

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10.3390/diagnostics11060928

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title = "Shear wave elastography in the detection of sinusoidal obstruction syndrome in adult patients undergoing allogenic hematopoietic stem cell transplantation",

abstract = "Hepatic sinusoidal obstruction syndrome (SOS), also known as veno-occlusive disease (VOD) can be a life-threatening complication after hematopoietic stem cell transplantation (HSCT). Diagnosis is often difficult and traditionally based on clinical parameters. Shear wave elastography (SWE) is a modern non-invasive liver stiffness measurement technique using ultrasound. In this monocentric study, we evaluated the role of SWE in diagnosing SOS/VOD in 63 adult patients undergoing HSCT from February 2020 to August 2020 in real world settings. Three patients devel-oped SOS/VOD. This was accompanied by an increase in shear wave velocity in all three patients, indicating that this method may contribute to establishing the diagnosis SOS/VOD after HSCT.",

keywords = "Hematopoietic stem cell transplantation (HSCT), Liver stiffness measurement (LSM), Shear wave elastography (SWE), Sinusoidal obstruction syndrome (SOS), Veno-occlusive disease (VOD)",

author = "Marten Schulz and Vuong, {Lam Giang} and M{\"u}ller, {Hans Peter} and Martin Maibier and Frank Tacke and Blau, {Igor Wolfgang} and Alexander Wree",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

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doi = "10.3390/diagnostics11060928",

language = "English",

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T1 - Shear wave elastography in the detection of sinusoidal obstruction syndrome in adult patients undergoing allogenic hematopoietic stem cell transplantation

AU - Schulz, Marten

AU - Vuong, Lam Giang

AU - Müller, Hans Peter

AU - Maibier, Martin

AU - Tacke, Frank

AU - Blau, Igor Wolfgang

AU - Wree, Alexander

PY - 2021/6

Y1 - 2021/6

N2 - Hepatic sinusoidal obstruction syndrome (SOS), also known as veno-occlusive disease (VOD) can be a life-threatening complication after hematopoietic stem cell transplantation (HSCT). Diagnosis is often difficult and traditionally based on clinical parameters. Shear wave elastography (SWE) is a modern non-invasive liver stiffness measurement technique using ultrasound. In this monocentric study, we evaluated the role of SWE in diagnosing SOS/VOD in 63 adult patients undergoing HSCT from February 2020 to August 2020 in real world settings. Three patients devel-oped SOS/VOD. This was accompanied by an increase in shear wave velocity in all three patients, indicating that this method may contribute to establishing the diagnosis SOS/VOD after HSCT.

AB - Hepatic sinusoidal obstruction syndrome (SOS), also known as veno-occlusive disease (VOD) can be a life-threatening complication after hematopoietic stem cell transplantation (HSCT). Diagnosis is often difficult and traditionally based on clinical parameters. Shear wave elastography (SWE) is a modern non-invasive liver stiffness measurement technique using ultrasound. In this monocentric study, we evaluated the role of SWE in diagnosing SOS/VOD in 63 adult patients undergoing HSCT from February 2020 to August 2020 in real world settings. Three patients devel-oped SOS/VOD. This was accompanied by an increase in shear wave velocity in all three patients, indicating that this method may contribute to establishing the diagnosis SOS/VOD after HSCT.

KW - Hematopoietic stem cell transplantation (HSCT)

KW - Liver stiffness measurement (LSM)

KW - Shear wave elastography (SWE)

KW - Sinusoidal obstruction syndrome (SOS)

KW - Veno-occlusive disease (VOD)

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ER -

Shear wave elastography in the detection of sinusoidal obstruction syndrome in adult patients undergoing allogenic hematopoietic stem cell transplantation

Abstract

Keywords

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