Shear wave elastography and shear wave dispersion imaging in the assessment of liver disease in alpha1-antitrypsin deficiency

Marten Schulz, Moritz Kleinjans, Pavel Strnad, Münevver Demir, Theresa M. Holtmann, Frank Tacke, Alexander Wree

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Liver affection of Alpha1-antitrypsin deficiency (AATD) can lead to cirrhosis and hepato-cellular carcinoma (HCC). A noninvasive severity assessment of liver disease in AATD is urgently needed since laboratory parameters may not accurately reflect the extent of liver involvement. Pre-liminary data exist on two-dimensional shear wave elastography (2D-SWE) being a suitable method for liver fibrosis measurement in AATD. AATD patients without HCC were examined using 2D-SWE, shear wave dispersion imaging (SWD) and transient elastography (TE). Furthermore, liver steatosis was assessed using the controlled attenuation parameter (CAP) and compared to the new method of attenuation imaging (ATI). 29 AATD patients were enrolled, of which 18 had the PiZZ genotype, eight had PiMZ, two had PiSZ and one had a PiZP-Lowell genotype. 2D-SWE (median 1.42 m/S, range 1.14–1.83 m/S) and TE (median 4.8 kPa, range 2.8–24.6 kPa) values displayed a significant correlation (R = 0.475, p < 0.05). 2D-SWE, ATI (median 0.56 dB/cm/MHz, range 0.43–0.96 dB/cm/MHz) and CAP (median 249.5 dB/m, range 156–347 dB/m) values were higher in PiZZ when compared to other AATD genotypes. This study provides evidence that 2D-SWE is a suitable method for the assessment of liver disease in AATD. The newer methods of SWD and ATI require further evaluation in the context of AATD.

Original languageEnglish
Article number629
JournalDiagnostics
Volume11
Issue number4
DOIs
StatePublished - Apr 2021
Externally publishedYes

Keywords

  • Alpha1-antitrypsin deficiency (AATD)
  • Shear wave dispersion (SWD)
  • Shear wave elastography (SWE)

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