Shared genetic background between children and adults with attention deficit/hyperactivity disorder

Paula Rovira; Ditte Demontis; Cristina Sánchez-Mora; Tetyana Zayats; Marieke Klein; Nina Roth Mota; Heike Weber; Iris Garcia-Martínez; Mireia Pagerols; Laura Vilar-Ribó; Lorena Arribas; Vanesa Richarte; Montserrat Corrales; Christian Fadeuilhe; Rosa Bosch; Gemma Español Martin; Peter Almos; Alysa E. Doyle; Eugenio Horacio Grevet; Oliver Grimm; Anne Halmøy; Martine Hoogman; Mara Hutz; Christian P. Jacob; Sarah Kittel-Schneider; Per M. Knappskog; Astri J. Lundervold; Olga Rivero; Diego Luiz Rovaris; Angelica Salatino-Oliveira; Bruna Santos da Silva; Evgeniy Svirin; Emma Sprooten; Tatyana Strekalova; Alejandro Arias-Vasquez; Edmund J.S. Sonuga-Barke; Philip Asherson; Claiton Henrique Dotto Bau; Jan K. Buitelaar; Bru Cormand; Stephen V. Faraone; Jan Haavik; Stefan E. Johansson; Jonna Kuntsi; Henrik Larsson; Klaus Peter Lesch; Andreas Reif; Luis Augusto Rohde; Miquel Casas; Anders D. Børglum; Barbara Franke; Josep Antoni Ramos-Quiroga; María Soler Artigas; Marta Ribasés

doi:10.1038/s41386-020-0664-5

Shared genetic background between children and adults with attention deficit/hyperactivity disorder

Paula Rovira, Ditte Demontis, Cristina Sánchez-Mora, Tetyana Zayats, Marieke Klein, Nina Roth Mota, Heike Weber, Iris Garcia-Martínez, Mireia Pagerols, Laura Vilar-Ribó, Lorena Arribas, Vanesa Richarte, Montserrat Corrales, Christian Fadeuilhe, Rosa Bosch, Gemma Español Martin, Peter Almos, Alysa E. Doyle, Eugenio Horacio Grevet, Oliver GrimmAnne Halmøy, Martine Hoogman, Mara Hutz, Christian P. Jacob, Sarah Kittel-Schneider, Per M. Knappskog, Astri J. Lundervold, Olga Rivero, Diego Luiz Rovaris, Angelica Salatino-Oliveira, Bruna Santos da Silva, Evgeniy Svirin, Emma Sprooten, Tatyana Strekalova, Alejandro Arias-Vasquez, Edmund J.S. Sonuga-Barke, Philip Asherson, Claiton Henrique Dotto Bau, Jan K. Buitelaar, Bru Cormand, Stephen V. Faraone, Jan Haavik, Stefan E. Johansson, Jonna Kuntsi, Henrik Larsson, Klaus Peter Lesch, Andreas Reif, Luis Augusto Rohde, Miquel Casas, Anders D. Børglum, Barbara Franke, Josep Antoni Ramos-Quiroga, María Soler Artigas, Marta Ribasés

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Abstract

Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by age-inappropriate symptoms of inattention, impulsivity, and hyperactivity that persist into adulthood in the majority of the diagnosed children. Despite several risk factors during childhood predicting the persistence of ADHD symptoms into adulthood, the genetic architecture underlying the trajectory of ADHD over time is still unclear. We set out to study the contribution of common genetic variants to the risk for ADHD across the lifespan by conducting meta-analyses of genome-wide association studies on persistent ADHD in adults and ADHD in childhood separately and jointly, and by comparing the genetic background between them in a total sample of 17,149 cases and 32,411 controls. Our results show nine new independent loci and support a shared contribution of common genetic variants to ADHD in children and adults. No subgroup heterogeneity was observed among children, while this group consists of future remitting and persistent individuals. We report similar patterns of genetic correlation of ADHD with other ADHD-related datasets and different traits and disorders among adults, children, and when combining both groups. These findings confirm that persistent ADHD in adults is a neurodevelopmental disorder and extend the existing hypothesis of a shared genetic architecture underlying ADHD and different traits to a lifespan perspective.

Original language	English
Pages (from-to)	1617-1626
Number of pages	10
Journal	Neuropsychopharmacology
Volume	45
Issue number	10
DOIs	https://doi.org/10.1038/s41386-020-0664-5
State	Published - 1 Sep 2020
Externally published	Yes

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Rovira, P., Demontis, D., Sánchez-Mora, C., Zayats, T., Klein, M., Mota, N. R., Weber, H., Garcia-Martínez, I., Pagerols, M., Vilar-Ribó, L., Arribas, L., Richarte, V., Corrales, M., Fadeuilhe, C., Bosch, R., Martin, G. E., Almos, P., Doyle, A. E., Grevet, E. H., ... Ribasés, M. (2020). Shared genetic background between children and adults with attention deficit/hyperactivity disorder. Neuropsychopharmacology, 45(10), 1617-1626. https://doi.org/10.1038/s41386-020-0664-5

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title = "Shared genetic background between children and adults with attention deficit/hyperactivity disorder",

abstract = "Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by age-inappropriate symptoms of inattention, impulsivity, and hyperactivity that persist into adulthood in the majority of the diagnosed children. Despite several risk factors during childhood predicting the persistence of ADHD symptoms into adulthood, the genetic architecture underlying the trajectory of ADHD over time is still unclear. We set out to study the contribution of common genetic variants to the risk for ADHD across the lifespan by conducting meta-analyses of genome-wide association studies on persistent ADHD in adults and ADHD in childhood separately and jointly, and by comparing the genetic background between them in a total sample of 17,149 cases and 32,411 controls. Our results show nine new independent loci and support a shared contribution of common genetic variants to ADHD in children and adults. No subgroup heterogeneity was observed among children, while this group consists of future remitting and persistent individuals. We report similar patterns of genetic correlation of ADHD with other ADHD-related datasets and different traits and disorders among adults, children, and when combining both groups. These findings confirm that persistent ADHD in adults is a neurodevelopmental disorder and extend the existing hypothesis of a shared genetic architecture underlying ADHD and different traits to a lifespan perspective.",

author = "Paula Rovira and Ditte Demontis and Cristina S{\'a}nchez-Mora and Tetyana Zayats and Marieke Klein and Mota, {Nina Roth} and Heike Weber and Iris Garcia-Mart{\'i}nez and Mireia Pagerols and Laura Vilar-Rib{\'o} and Lorena Arribas and Vanesa Richarte and Montserrat Corrales and Christian Fadeuilhe and Rosa Bosch and Martin, {Gemma Espa{\~n}ol} and Peter Almos and Doyle, {Alysa E.} and Grevet, {Eugenio Horacio} and Oliver Grimm and Anne Halm{\o}y and Martine Hoogman and Mara Hutz and Jacob, {Christian P.} and Sarah Kittel-Schneider and Knappskog, {Per M.} and Lundervold, {Astri J.} and Olga Rivero and Rovaris, {Diego Luiz} and Angelica Salatino-Oliveira and Silva, {Bruna Santos da} and Evgeniy Svirin and Emma Sprooten and Tatyana Strekalova and Alejandro Arias-Vasquez and Sonuga-Barke, {Edmund J.S.} and Philip Asherson and {Dotto Bau}, {Claiton Henrique} and Buitelaar, {Jan K.} and Bru Cormand and Faraone, {Stephen V.} and Jan Haavik and Johansson, {Stefan E.} and Jonna Kuntsi and Henrik Larsson and Lesch, {Klaus Peter} and Andreas Reif and Rohde, {Luis Augusto} and Miquel Casas and B{\o}rglum, {Anders D.} and Barbara Franke and Ramos-Quiroga, {Josep Antoni} and Artigas, {Mar{\'i}a Soler} and Marta Ribas{\'e}s",

note = "Publisher Copyright: {\textcopyright} 2020, The Author(s).",

year = "2020",

month = sep,

day = "1",

doi = "10.1038/s41386-020-0664-5",

language = "English",

volume = "45",

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Rovira, P, Demontis, D, Sánchez-Mora, C, Zayats, T, Klein, M, Mota, NR, Weber, H, Garcia-Martínez, I, Pagerols, M, Vilar-Ribó, L, Arribas, L, Richarte, V, Corrales, M, Fadeuilhe, C, Bosch, R, Martin, GE, Almos, P, Doyle, AE, Grevet, EH, Grimm, O, Halmøy, A, Hoogman, M, Hutz, M, Jacob, CP, Kittel-Schneider, S, Knappskog, PM, Lundervold, AJ, Rivero, O, Rovaris, DL, Salatino-Oliveira, A, Silva, BSD, Svirin, E, Sprooten, E, Strekalova, T, Arias-Vasquez, A, Sonuga-Barke, EJS, Asherson, P, Dotto Bau, CH, Buitelaar, JK, Cormand, B, Faraone, SV, Haavik, J, Johansson, SE, Kuntsi, J, Larsson, H, Lesch, KP, Reif, A, Rohde, LA, Casas, M, Børglum, AD, Franke, B, Ramos-Quiroga, JA, Artigas, MS & Ribasés, M 2020, 'Shared genetic background between children and adults with attention deficit/hyperactivity disorder', Neuropsychopharmacology, vol. 45, no. 10, pp. 1617-1626. https://doi.org/10.1038/s41386-020-0664-5

TY - JOUR

T1 - Shared genetic background between children and adults with attention deficit/hyperactivity disorder

AU - Rovira, Paula

AU - Demontis, Ditte

AU - Sánchez-Mora, Cristina

AU - Zayats, Tetyana

AU - Klein, Marieke

AU - Mota, Nina Roth

AU - Weber, Heike

AU - Garcia-Martínez, Iris

AU - Pagerols, Mireia

AU - Vilar-Ribó, Laura

AU - Arribas, Lorena

AU - Richarte, Vanesa

AU - Corrales, Montserrat

AU - Fadeuilhe, Christian

AU - Bosch, Rosa

AU - Martin, Gemma Español

AU - Almos, Peter

AU - Doyle, Alysa E.

AU - Grevet, Eugenio Horacio

AU - Grimm, Oliver

AU - Halmøy, Anne

AU - Hoogman, Martine

AU - Hutz, Mara

AU - Jacob, Christian P.

AU - Kittel-Schneider, Sarah

AU - Knappskog, Per M.

AU - Lundervold, Astri J.

AU - Rivero, Olga

AU - Rovaris, Diego Luiz

AU - Salatino-Oliveira, Angelica

AU - Silva, Bruna Santos da

AU - Svirin, Evgeniy

AU - Sprooten, Emma

AU - Strekalova, Tatyana

AU - Arias-Vasquez, Alejandro

AU - Sonuga-Barke, Edmund J.S.

AU - Asherson, Philip

AU - Dotto Bau, Claiton Henrique

AU - Buitelaar, Jan K.

AU - Cormand, Bru

AU - Faraone, Stephen V.

AU - Haavik, Jan

AU - Johansson, Stefan E.

AU - Kuntsi, Jonna

AU - Larsson, Henrik

AU - Lesch, Klaus Peter

AU - Reif, Andreas

AU - Rohde, Luis Augusto

AU - Casas, Miquel

AU - Børglum, Anders D.

AU - Franke, Barbara

AU - Ramos-Quiroga, Josep Antoni

AU - Artigas, María Soler

AU - Ribasés, Marta

PY - 2020/9/1

Y1 - 2020/9/1

N2 - Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by age-inappropriate symptoms of inattention, impulsivity, and hyperactivity that persist into adulthood in the majority of the diagnosed children. Despite several risk factors during childhood predicting the persistence of ADHD symptoms into adulthood, the genetic architecture underlying the trajectory of ADHD over time is still unclear. We set out to study the contribution of common genetic variants to the risk for ADHD across the lifespan by conducting meta-analyses of genome-wide association studies on persistent ADHD in adults and ADHD in childhood separately and jointly, and by comparing the genetic background between them in a total sample of 17,149 cases and 32,411 controls. Our results show nine new independent loci and support a shared contribution of common genetic variants to ADHD in children and adults. No subgroup heterogeneity was observed among children, while this group consists of future remitting and persistent individuals. We report similar patterns of genetic correlation of ADHD with other ADHD-related datasets and different traits and disorders among adults, children, and when combining both groups. These findings confirm that persistent ADHD in adults is a neurodevelopmental disorder and extend the existing hypothesis of a shared genetic architecture underlying ADHD and different traits to a lifespan perspective.

AB - Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by age-inappropriate symptoms of inattention, impulsivity, and hyperactivity that persist into adulthood in the majority of the diagnosed children. Despite several risk factors during childhood predicting the persistence of ADHD symptoms into adulthood, the genetic architecture underlying the trajectory of ADHD over time is still unclear. We set out to study the contribution of common genetic variants to the risk for ADHD across the lifespan by conducting meta-analyses of genome-wide association studies on persistent ADHD in adults and ADHD in childhood separately and jointly, and by comparing the genetic background between them in a total sample of 17,149 cases and 32,411 controls. Our results show nine new independent loci and support a shared contribution of common genetic variants to ADHD in children and adults. No subgroup heterogeneity was observed among children, while this group consists of future remitting and persistent individuals. We report similar patterns of genetic correlation of ADHD with other ADHD-related datasets and different traits and disorders among adults, children, and when combining both groups. These findings confirm that persistent ADHD in adults is a neurodevelopmental disorder and extend the existing hypothesis of a shared genetic architecture underlying ADHD and different traits to a lifespan perspective.

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U2 - 10.1038/s41386-020-0664-5

DO - 10.1038/s41386-020-0664-5

M3 - Article

C2 - 32279069

AN - SCOPUS:85084050907

SN - 0893-133X

VL - 45

SP - 1617

EP - 1626

JO - Neuropsychopharmacology

JF - Neuropsychopharmacology

IS - 10

ER -

Shared genetic background between children and adults with attention deficit/hyperactivity disorder

Abstract

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