TY - JOUR
T1 - Sexually Acquired Hepatitis C Infection in HIV-Uninfected Men Who Have Sex with Men Using Preexposure Prophylaxis against HIV
AU - Price, Jennifer C.
AU - Mckinney, Jeffrey E.
AU - Crouch, Pierre Cedric
AU - Dillon, Stephen M.
AU - Radix, Asa
AU - Stivala, Alicia
AU - Carollo, Jesse R.
AU - Fierer, Daniel S.
N1 - Publisher Copyright:
© 2018 The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].
PY - 2019/4/16
Y1 - 2019/4/16
N2 - Sexually acquired hepatitis C virus (HCV) infections among human immunodeficiency virus (HIV)-uninfected men who have sex with men (MSM) have been rare. With the introduction of preexposure prophylaxis (PrEP) against HIV, we hypothesized that these infections would increase. Between 2013 and 2018, we diagnosed 15 likely sexually acquired HCV infections among 14 MSM using PrEP. Most (87%) were asymptomatic, detected by routine alanine transaminase (ALT) or HCV monitoring. Half reported increasing sex partners and drug use after starting PrEP; 5 reported injection of methamphetamine. Interventions are needed to prevent sexually acquired HCV infections by MSM using PrEP. Centers for Disease Control and Prevention guidelines for monitoring during PrEP should include regular ALT and HCV testing.
AB - Sexually acquired hepatitis C virus (HCV) infections among human immunodeficiency virus (HIV)-uninfected men who have sex with men (MSM) have been rare. With the introduction of preexposure prophylaxis (PrEP) against HIV, we hypothesized that these infections would increase. Between 2013 and 2018, we diagnosed 15 likely sexually acquired HCV infections among 14 MSM using PrEP. Most (87%) were asymptomatic, detected by routine alanine transaminase (ALT) or HCV monitoring. Half reported increasing sex partners and drug use after starting PrEP; 5 reported injection of methamphetamine. Interventions are needed to prevent sexually acquired HCV infections by MSM using PrEP. Centers for Disease Control and Prevention guidelines for monitoring during PrEP should include regular ALT and HCV testing.
KW - acute hepatitis C virus
KW - men who have sex with men
KW - methamphetamine
KW - preexposure prophylaxis
KW - sexual transmission
UR - https://www.scopus.com/pages/publications/85061918163
U2 - 10.1093/infdis/jiy670
DO - 10.1093/infdis/jiy670
M3 - Article
C2 - 30462305
AN - SCOPUS:85061918163
SN - 0022-1899
VL - 219
SP - 1373
EP - 1376
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 9
M1 - jiy670
ER -