@article{1ea03199cce0438ea11f3fc329d2bb50,
title = "Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue",
abstract = "Subcutaneous white adipose tissue (scWAT) is a dynamic storage and secretory organ that regulates systemic homeostasis, yet the impact of endurance exercise training (ExT) and sex on its molecular landscape is not fully established. Utilizing an integrative multi-omics approach, and leveraging data generated by the Molecular Transducers of Physical Activity Consortium (MoTrPAC), we show profound sexual dimorphism in the scWAT of sedentary rats and in the dynamic response of this tissue to ExT. Specifically, the scWAT of sedentary females displays -omic signatures related to insulin signaling and adipogenesis, whereas the scWAT of sedentary males is enriched in terms related to aerobic metabolism. These sex-specific -omic signatures are preserved or amplified with ExT. Integration of multi-omic analyses with phenotypic measures identifies molecular hubs predicted to drive sexually distinct responses to training. Overall, this study underscores the powerful impact of sex on adipose tissue biology and provides a rich resource to investigate the scWAT response to ExT.",
author = "{the MoTrPAC Study Group} and Many, {Gina M.} and Sanford, {James A.} and Sagendorf, {Tyler J.} and Zhenxin Hou and Pasquale Nigro and Whytock, {Katie L.} and David Amar and Tiziana Caputo and Gay, {Nicole R.} and Gaul, {David A.} and Hirshman, {Michael F.} and David Jimenez-Morales and Lindholm, {Malene E.} and Muehlbauer, {Michael J.} and Maria Vamvini and Bergman, {Bryan C.} and Fern{\'a}ndez, {Facundo M.} and Goodyear, {Laurie J.} and Hevener, {Andrea L.} and Ortlund, {Eric A.} and Sparks, {Lauren M.} and Ashley Xia and Adkins, {Joshua N.} and Bodine, {Sue C.} and Newgard, {Christopher B.} and Simon Schenk and Armenteros, {Jose Juan Almagro} and Amper, {Mary Anne S.} and Euan Ashley and Asokan, {Aneesh Kumar} and Julian Avila-Pacheco and Dam Bae and Bamman, {Marcas M.} and Nasim Bararpour and Jerry Barnes and Buford, {Thomas W.} and Burant, {Charles F.} and Carbone, {Nicholas P.} and Carr, {Steven A.} and Chambers, {Toby L.} and Clarisa Chavez and Roxanne Chiu and Clish, {Clary B.} and Cutter, {Gary R.} and Yongchao Ge and Venugopalan Nair and Sealfon, {Stuart C.} and Smith, {Gregory R.} and Walsh, {Martin J.} and Elena Zaslavsky",
note = "Publisher Copyright: {\textcopyright} Battelle Memorial Institute 2024.",
year = "2024",
month = may,
doi = "10.1038/s42255-023-00959-9",
language = "English",
volume = "6",
pages = "963--979",
journal = "Nature Metabolism",
issn = "2522-5812",
publisher = "Springer Berlin",
number = "5",
}